Research Progress of Next Generation Sequencing in Acute Leukemia --Review / 中国实验血液学杂志

With the advent of precision medicine, next-generation sequencing (NGS) is playing an increasingly important role in clinical oncology diagnosis and treatment with its advantages of high sensitivity, high accuracy, high efficiency and operability. NGS reveals the genetic characteristics of acute leukemia(AL) patients by screening for specific disease-causing genes to identify occult as well as complex genetic mutations in patients with AL, leading to early diagnosis and targeted drug therapy for AL patients, as well as to predict disease recurrence by detecting mnimal residual disease (MRD) and analyzing mutated genes to determine patient prognosis. NGS plays an increasingly important role in the diagnosis, treatment and prognosis assessment in AL, providing a direction for the pursuit of precision medicine. This paper reviews the research progress of NGS in AL.

Mechanical performances of endovascular aneurysm repair strategies with main aortic and chimney grafts.

The use of endovascular aneurysm repair (EVAR) strategies for the treatment of complex aortic pathologies is a major area of investigation in modern surgery. EVAR strategies using fenestrated or branched devices provide alternatives to open surgery for patients with aortic pathologies with visceral branch involvement, but their applications have some major limitations. To extend endovascular repair to patients whose anatomy is unfit for branched or fenestrated stent grafts or open repair, parallel graft techniques using chimney grafts (CGs) have been proposed. Several recent series have confirmed that the midterm durability of CGs is similar to that of other endovascular repair techniques. However, the risk of a persistent type 1 endoleak, or gutter endoleak, is a major concern for their further application. In addition, the combinations of CGs with various brands of main aortic graft (MAG) that are applicable for use in patients remain unclear. This study aimed to determine the radial forces developed by different brands of MAG and their effects on CGs, and the real gutter condition produced between the CGs and main stent grafts.

Clinical and pathological features of IgA nephropathy in west Guangdong province / 南方医科大学学报

<p><b>OBJECTIVE</b>To analyze the pathological and clinical features of IgA nephropathy (IgAN) in west Guangdong province.</p><p><b>METHODS</b>The pathological type and clinical features of 120 patients with IgAN were retrospectively analyzed.</p><p><b>RESULTS</b>Mesangial proliferative glomerulonephritis and focal segmental glomerulosclerosis were the most frequent features of IgAN. IgM deposit could be found in half of the IgAN patients, especially in the IgAN patients with focal segmental glomerulosclerosis.</p><p><b>CONCLUSION</b>The incidence of IgAN may vary between different regions. Clinically, misdiagnosis of other renal diseases as IgAN may often occur. The nature and severity of glomerular immunoglobulin deposition can be related to the pathogenesis and progression of IgAN.</p>