Reverse Separation of Carbon Dioxide and Acetylene in Two Isostructural Copper Pyridine-Carboxylate Frameworks.

Separating acetylene from carbon dioxide is important but highly challenging due to their similar molecular shapes and physical properties. Adsorptive separation of carbon dioxide from acetylene can directly produce pure acetylene but is hardly realized because of relatively polarizable acetylene binds more strongly. Here, we reverse the CO2 and C2H2 separation by adjusting the pore structures in two isoreticular ultramicroporous metal-organic frameworks (MOFs). Under ambient conditions, copper isonicotinate (Cu(ina)2), with relatively large pore channels shows C2H2-selective adsorption with a C2H2/CO2 selectivity of 3.4, whereas its smaller-pore analogue, copper quinoline-5-carboxylate (Cu(Qc)2) shows an inverse CO2/C2H2 selectivity of 5.6. Cu(Qc)2 shows compact pore space that well matches the optimal orientation of CO2 but is not compatible for C2H2. Neutron powder diffraction experiments confirmed that CO2 molecules adopt preferential orientation along the pore channels during adsorption binding, whereas C2H2 molecules bind in an opposite fashion with distorted configurations due to their opposite quadrupole moments. Dynamic breakthrough experiments have validated the separation performance of Cu(Qc)2 for CO2/C2H2 separation.

Prevalence and associated factors of alexithymia among people living with HIV/AIDS in China: a cross-sectional study.

BACKGROUND: Alexithymia is common and causes serious harm to people living with HIV/AIDS. Therefore, this study aimed to examine its prevalence and associated factors among people living with HIV/AIDS in China. METHODS: A cross-sectional study was conducted in two designated AIDS medical institutions in Harbin, China between January and December 2019. In total, 767 participants completed the 20-item Toronto Alexithymia Scale, the University of California Los Angeles Loneliness short-form, the Patient Health Questionnaire-9, the HIV Treatment Regimen Fatigue Scale, and the Alcohol Use Disorders Identification Test-Consumption. The participants responded to several questions regarding their demographic characteristics, life satisfaction, disease-related economic burden, and their antiretroviral therapy (ART) side effects. Multivariate logistic regression assessed the relationship between alexithymia and associated factors. Odds ratios (OR) and 95% confidence intervals (CI) for OR were calculated. RESULTS: Approximately 36.1% of the participants were classified as having alexithymia. After adjusted age and education, the logistic regression model indicated that disease-related economic burden (OR = 1.477, 95% CI = 1.155-1.888), ART side effects (OR = 1.249, 95% CI = 1.001-1.559), loneliness (OR = 1.166, 95% CI = 1.101-1.236), and HIV treatment regimen fatigue (OR = 1.028, 95% CI = 1.017-1.039) were positively associated with alexithymia. CONCLUSIONS: The mental health problems of people living with HIV/AIDS are essential to understand and deserve attention. Disease-related economic burdens are major associated factors. Multiple actors should provide better services and guarantees for patients.

Optimized Sieving Effect for Ethanol/Water Separation by Ultramicroporous MOFs.

High-purity ethanol is a promising renewable energy resource, however separating ethanol from trace amount of water is extremely challenging. Herein, two ultramicroporous MOFs (UTSA-280 and Co-squarate) were used as adsorbents. A prominent water adsorption and a negligible ethanol adsorption identify perfect sieving effect on both MOFs. Co-squarate exhibits a surprising water adsorption capacity at low pressure that surpassing the reported MOFs. Single crystal X-ray diffraction and theoretical calculations reveal that such prominent performance of Co-squarate derives from the optimized sieving effect through pore structure adjustment. Co-squarate with larger rhombohedral channel is suitable for zigzag water location, resulting in reinforced guest-guest and guest-framework interactions. Ultrapure ethanol (99.9 %) can be obtained directly by ethanol/water mixed vapor breaking through the columns packed with Co-squarate, contributing to a potential for fuel-grade ethanol purification.

Hydrogen-Bonded Organic Framework to Upgrade Cycling Stability and Rate Capability of Li-CO2 Batteries.

Elaborately designed multifunctional electrocatalysts capable of promoting Li+ and CO2 transport are essential for upgrading the cycling stability and rate capability of Li-CO2 batteries. Hydrogen-bonded organic frameworks (HOFs) with open channels and easily functionalized surfaces hold great potential for applications in efficient cathodes of Li-CO2 batteries. Herein, a robust HOFS (HOF-FJU-1) is introduced for the first time as a co-catalyst in the cathode material of Li-CO2 batteries. HOF-FJU-1 with cyano groups located periodically in the pore can induce homogeneous deposition of discharge products and accommodate volumetric expansion of discharge products during cycling. Besides, HOF-FJU-1 enables effective interaction between Ru0 nanoparticles and cyano groups, thus forming efficient and uniform catalytic sites for CRR/CER. Moreover, HOF-FJU-1 with regularly arranged open channels are beneficial for CO2 and Li+ transport, enabling rapid redox kinetic conversion of CO2 . Therefore, the HOF-based Li-CO2 batteries are capable of stable operation at 400 mA g-1 for 1800 h and maintain a low overpotential of 1.96 V even at high current densities up to 5 A g-1 . This work provides valuable guidance for developing multifunctional HOF-based catalysts to upgrade the longevity and rate capability of Li-CO2 batteries.

Tetranuclear CuII Cluster as the Ten Node Building Unit for the Construction of a Metal-Organic Framework for Efficient C2 H2 /CO2 Separation.

Rational design of high nuclear copper cluster-based metal-organic frameworks has not been established yet. Herein, we report a novel MOF (FJU-112) with the ten-connected tetranuclear copper cluster [Cu4 (PO3 )2 (µ2 -H2 O)2 (CO2 )4 ] as the node which was capped by the deprotonated organic ligand of H4 L (3,5-Dicarboxyphenylphosphonic acid). With BPE (1,2-Bis(4-pyridyl)ethane) as the pore partitioner, the pore spaces in the structure of FJU-112 were divided into several smaller cages and smaller windows for efficient gas adsorption and separation. FJU-112 exhibits a high separation performance for the C2 H2 /CO2 separation, which were established by the temperature-dependent sorption isotherms and further confirmed by the lab-scale dynamic breakthrough experiments. The grand canonical Monte Carlo simulations (GCMC) studies show that its high C2 H2 /CO2 separation performance is contributed to the strong π-complexation interactions between the C2 H2 molecules and framework pore surfaces, leading to its more C2 H2 uptakes over CO2 molecules.

Ultramicroporous Hydrogen-Bonded Organic Framework Material with a Thermoregulatory Gating Effect for Record Propylene Separation.

Propane/propylene separation is one of the most challenging and energy-consuming but most important tasks in the petrochemical industry. Herein, a stable hydrogen-bonded organic framework (HOF-FJU-1) was tailor-made for highly efficient propylene separation from binary C3H6/C3H8 and even seven component CH4/C2H4/C2H6/C3H6/C3H8/CO2/H2 mixtures. The temperature-controllable diffusion channels in HOF-FJU-1 have enabled the porous material to completely exclude propane to reach high-performance propylene purification under energy-efficient operation conditions. Single-crystal structural analysis revealed that the well-matched pore aperture of HOF-FJU-1 can exactly accommodate propylene molecules via multiple intermolecular interactions, exhibiting a very high propylene/propane selectivity of 616 at 333 K. The propylene purity and productivity are over 99.5% and 30.2 L kg-1 from the binary C3H6/C3H8 (50/50) mixture at 333 K. Through a follow-up column separation of C3H6/C2H4 at 353 K, not only high-purity propylene (99.5%) but also ethylene (98.3%) can be readily collected from the seven component CH4/C2H4/C2H6/C3H6/C3H8/CO2/H2 (31/10/25/10/10/1/13) cracking gas mixtures. The great potential of HOF-FJU-1 for the industrial propylene separation process has been further supported by the high stability of this porous material under different environments and straightforward processibility and regeneration feasibility.

Long non-coding RNA NRSN2-AS1 facilitates tumorigenesis and progression of ovarian cancer via miR-744-5p/PRKX axis.

Newly discovered lncRNA neurensin-2 antisense RNA 1 (NRSN2-AS1) has not been well explored in cancers. Ovarian cancer (OV) is a primary gynecologic cancer worldwide and has the highest mortality rate among gynecologic cancers. Hence, the role and underlying mechanisms of NRSN2-AS1 in OV were worth investigating. According to the results of qantitative real-time polymerase chain reaction, NRSN2-AS1 displayed the remarkably high expression in OV cells, in contrast to human ovarian epithelial cells. Based on online database, the expression level of NRSN2-AS1 was significantly higher in OV tissues than that in normal ovarian tissues. The data from functional experiments indicated that NRSN2-AS1 knockdown inhibited OV cell malignant behaviors in vitro and OV tumor growth in vivo. Moreover, mechanism analysis unveiled that NRSN2-AS1 functioned as a miR-744-5p sponge to regulate PRKX expression in OV cells. The results of TOP/FOP flash and western blot assays suggested that NRSN2-AS1/miR-744-5p/PRKX axis modulated the activity of Wnt/ß-catenin signaling pathway. In summary, we validated NRSN2-AS1 functioned as a novel oncogenic lncRNA in OV and elucidated its specific molecular mechanism. This work might advance our understanding of OV and provide evidence for supporting NRSN2-AS1 as a potential biomarker for OV treatment.

Identification of CEACAM5 as a stemness-related inhibitory immune checkpoint in pancreatic cancer.

BACKGROUND: Immunotherapy has emerged as a new cancer treatment modality. However, tumour heterogeneity can diminish checkpoint blockade response and shorten patient survival. As a source of tumour heterogeneity, cancer stem cells act as an indispensable reservoir for local recurrence and distant metastasis. Thus, precision immunotherapy targeting tumour heterogeneity requires a comprehensive understanding of cancer stem cell immunology. Our study aimed to identify stemness-related inhibitory immune checkpoints and relevant regulatory pathways in pancreatic cancer. METHODS: Pancreatic cancer-specific datasets in The Cancer Genome Atlas and the Cancer Therapeutics Response Portal were collected for in-depth bioinformatic analysis. Differentially expressed genes between pancreatic cancers with high and low stemness index (mRNAsi) scores were compared to screen out inhibitory immune checkpoints. Survival analysis was used to predict the prognostic value of immune checkpoint plus immune infiltrate in patients with pancreatic cancer. The expression of stemness-related immune checkpoint across immune subtypes of pancreatic cancer was detected and gene set enrichment analysis was performed to figure out the relevant regulatory signallings. RESULTS: The abundance of cancer stemness predicted a low immunotherapy response to pancreatic cancer. The inhibitory immune checkpoint CEACAM5 that was enriched in pancreatic cancers with high mRNAsi scores also exhibited a strong correlation with invasive cell-enriched signature and Msi+ tumour-initiating cell-enriched signature. Levels of CEACAM5 expression were higher in the interferon-γ dominant immune subtype of pancreatic cancers that are characterized by high M1 macrophage infiltration. The patient group with high levels of CEACAM5 expression had a high risk of poor overall survival, even if accompanied by high infiltration of M1 macrophages. Furthermore, prostanoid and long-chain unsaturated fatty acid metabolic processes showed a significant association with cancer stemness and CEACAM5 expression. CONCLUSIONS: Our findings suggest that CEACAM5 is a candidate stemness-related innate immune checkpoint in pancreatic cancer, and is potentially regulated by prostanoid and long-chain unsaturated fatty acid metabolic processes. Immune checkpoint blockade of CEACAM5, which synergizes with inhibition of those regulatory pathways, may improve the efficacy of precision immunotherapy targeting tumour heterogeneity caused by cancer stem cells.

An Ultramicroporous Hydrogen-Bonded Organic Framework Exhibiting High C2 H2 /CO2 Separation.

The separation of C2 H2 /CO2 is not only industrially important for acetylene purification but also great scientific challenge due to their very similar molecular size and physical properties. To address this difficulty, herein, we present an ultramicroporous hydrogen-bonded organic framework (HOF-FJU-1) from tetracyano bicarbazole to separate C2 H2 from CO2 by taking advantage of differences in their electrostatic potential distribution. This material possesses a suitable pore environment and electrostatic potential distribution fitting well to C2 H2 , thus showing extra strong affinity to C2 H2 (46.73 kJ mol-1 ) and the highest IAST selectivity of 6675 for C2 H2 /CO2 separation among the adsorbents reported. The single crystal X-ray diffraction reveals that the suitable pore environment in HOF-FJU-1 provides multiple C-H⋅⋅⋅π and hydrogen-bonded interactions N⋅⋅⋅H-C with C2 H2 molecules. Dynamic breakthrough experiments demonstrate its outstanding separation performance to C2 H2 /CO2 mixtures.

A Flexible Hydrogen-Bonded Organic Framework Constructed from a Tetrabenzaldehyde with a Carbazole N-H Binding Site for the Highly Selective Recognition and Separation of Acetone.

Rational design of hydrogen-bonded organic frameworks (HOFs) with multiple functionalities is highly sought after but challenging. Herein, we report a multifunctional HOF (HOF-FJU-2) built from 4,4',4'',4'''-(9H-carbazole-1,3,6,8-tetrayl)tetrabenzaldehyde molecule with tetrabenzaldeyde for their H bonding interactions and carbazole N-H site for its specific recognition of small molecules. The Lewis acid N-H sites allow HOF-FJU-2 facilely separate acetone from its mixture with another solvent like methanol with smaller pKa value. The donor (D)-π-acceptor (A) aromatic nature of the organic building molecule endows this HOF with solvent dependent luminescent/chromic properties, so the column acetone/methanol separation on HOF-FJU-2 can be readily visualized.

Pure Metal-Organic Framework Microlasers with Controlled Cavity Shapes.

Metal-organic frameworks (MOFs) are an emerging kind of laser material, yet they remain a challenge in the controlled fabrication of crystal nanostructures with desired morphology for tuning their optical microcavities. Herein, the shape-engineering of pure MOF microlasers was demonstrated based on the coordination-mode-tailored method. The one-dimensional (1D) microwires and 2D microplates were selectively fabricated through changing the HCl concentration to tailor the coordination modes. Both the single-crystalline microwires and microplates with strong optical confinement functioned as low-threshold MOF microlasers. Moreover, distinct lasing behaviors of 1D and 2D MOF microcrystals confirm a typical shape-dependent microcavity effect: 1D microwires serve as Fabry-Pérot (FP) resonators, and 2D microplates lead to the whispering-gallery-mode (WGM) microcavities. These results provide a special pathway for the exploitation of MOF-based micro/nanolasers with on-demand functions.

Solvent-Assisted Modification to Enhance Proton Conductivity and Water Stability in Metal Phosphonates.

Although proton-conductive metal phosphonates with well-defined structure offer a favorable platform for exploring their structure-property relationship, investigating of the synergic effect of phosphonate groups and functional moieties on proton conduction is rare. In this work, we have synthesized two new copper phosphonates, [Cu(4-cppH)(4,4'-bipy)(H2O)3] (FJU-80) and [Cu(4-cppH)(4,4'-bipy)]·H2O·DMF (FJU-81), by the method of solvent-assisted modification, giving a 1D metal coordination polymer and a 3D metal open framework, respectively. Single-crystal X-ray diffraction shows that FJU-80 is full of hydrogen-bonding sites contributed from the improved synergic effect of phosphonate groups, carboxylate groups, and coordinated water molecules, thereby facilitating continuous hydrogen-bonding networks, whereas FJU-81 only has discrete hydrogen-bonding fragments. Powder X-ray diffraction and impedance analyses confirm that FJU-80 possesses higher water stability as well as improved proton conductivity, indicating that solvent-assisted modification is effective in increasing the hydrogen-bonding sites from phosphonate groups and functional moieties and then realizing facile proton transfer.

Structural and dynamical features of the 2,2,2-trifluoroethanolammonia complex.

The 1 : 1 adduct of 2,2,2-trifluoroethanol (TFE) with ammonia was investigated using a combination of chirped pulse and cavity-based Fourier transform microwave spectroscopy and computational methods. Rotational spectra of the most stable TFENH3 conformer and seven deuterium and 15N isotopologues were identified, and this led to a determination of partial rs and ro structures. The observed complex exhibits a gauche conformation of TFE with ammonia inserted into the existing intramolecular hydrogen-bonded ring of TFE. The adduct is stabilised by a delicate interplay between the primary O-HN hydrogen-bond and secondary N-HF interactions between TFE and ammonia. Evidence for several internal-dynamics effects was found in the rotational spectra. The ammonia subunit shows an almost free internal rotation. Tunneling between the gauche forms, g+ and g-, of TFE is quenched by the hydrogen-bond interactions with ammonia.

Steric-Hindrance-Controlled Laser Switch Based on Pure Metal-Organic Framework Microcrystals.

Herein, we demonstrated a steric-hindrance-controlled laser switch in pure metal-organic framework (MOF) microcrystals. The well-faceted MOF microwires with aggregation-induced emission (AIE) lumnogens as linkers function as typical Fabry-Pérot microlasers. The steric hindrance around the AIE linkers can be reduced by the loss of guest molecules, which lead to the enhanced rotation of linkers with red-shifted gain behavior. On this basis, the gain region was readily switched through changing the steric hindrance via the desorption/adsorption of guests. As a result, the reversible switching of the dual-wavelength lasing from MOF microwires was achieved. The results provide a promising route to the development of versatile micro-/nanolasers with desired applications.

Robustness, Selective Gas Separation, and Nitrobenzene Sensing on Two Isomers of Cadmium Metal-Organic Frameworks Containing Various Metal-O-Metal Chains.

Poor stability has been one of the major difficulties affecting to the practical application of metal-organic frameworks (MOFs). In this work, we obtained two 3D structurally isomeric Cd-MOFs, {[Cd6(NH2Me2)2(PTB)4(HCOO)2(H2O)]·(DMF)13·(H2O)4} n (FJU-35) and {[Cd6(NH2Me2)2(PTB)4(HCOO)2]·(DMF)6·(H2O)2} n (FJU-36) (H3PTB = pyridine-2,4,6-tribenzoic acid) containing different CdII-O-CdII chains by varying the addition agents. FJU-35 with coordinated solvent and formate in asymmetric µ3-η1:η2 coordination mode within the CdII-O-CdII chains is vulnerable to external attacks and is apt to collapse after activation, while FJU-36 with no coordinated solvent in the CdII-O-CdII chains but fully protected by the carboxylates from the ligands and the symmetric formate in the coordination mode µ3-η2:η2 is stable, and its activated sample shows efficient separation of C2H2/CH4 and C2H2/CO2 mixtures. Conversely, FJU-35 with more vulnerability is more sensitive to the detection of nitrobenzene than FJU-36.

Temperature-dependent molecular sieving of fluorinated propane/propylene mixtures by a flexible-robust metal-organic framework.

The electronics industry necessitates highly selective adsorption separation of hexafluoropropylene (C3F6) from perfluoropropane (C3F8), which poses a challenge due to their similar physiochemical properties. In this work, we present a microporous flexible-robust metal-organic framework (Ca-tcpb) with thermoregulatory gate opening, a rare phenomenon that allows tunable sieving of C3F8/C3F6. Remarkably, the temperature-dependent adsorption behavior enhances the discrimination between the larger C3F8 and the smaller C3F6, resulting in unprecedented C3F6/C3F8 selectivity (over 10,000) compared to other well-known porous materials at an optimal temperature (298 K). Dynamic breakthrough experiments demonstrate that high-purity C3F8 (over 99.999%) could be obtained from a C3F6/C3F8 (10:90) mixture under ambient conditions. The unique attributes of this material encompass exceptional adsorption selectivity, remarkable structural stability, and outstanding separation performance, positioning it as a highly promising candidate for C3F6/C3F8 separation. Single-crystal structural analysis of C3F6-loaded Ca-tcpb and theoretical calculations elucidate the host-guest interaction via multiple intermolecular interactions.

Multistate structures in a hydrogen-bonded polycatenation non-covalent organic framework with diverse resistive switching behaviors.

The inherent structural flexibility and reversibility of non-covalent organic frameworks have enabled them to exhibit switchable multistate structures under external stimuli, providing great potential in the field of resistive switching (RS), but not well explored yet. Herein, we report the 0D+1D hydrogen-bonded polycatenation non-covalent organic framework (HOF-FJU-52), exhibiting diverse and reversible RS behaviors with the high performance. Triggered by the external stimulus of electrical field E at room temperature, HOF-FJU-52 has excellent resistive random-access memory (RRAM) behaviors, comparable to the state-of-the-art materials. When cooling down below 200 K, it was transferred to write-once-read-many-times memory (WORM) behaviors. The two memory behaviors exhibit reversibility on a single crystal device through the temperature changes. The RS mechanism of this non-covalent organic framework has been deciphered at the atomic level by the detailed single-crystal X-ray diffraction analyses, demonstrating that the structural dual-flexibility both in the asymmetric hydrogen bonded dimers within the 0D loops and in the infinite π-π stacking column between the loops and chains contribute to reversible structure transformations between multi-states and thus to its dual RS behaviors.

Identification of ONECUT3 as a stemness-related transcription factor regulating NK cell-mediated immune evasion in pancreatic cancer.

Pancreatic ductal adenocarcinoma (PDAC) has a dismal response to the current T cell-based immunotherapies, which is attributed to intratumoral heterogeneity caused by PDAC stem cells and lack of major histocompatibility complex class I required for neoantigen presentation. Although this scenario makes natural killer (NK) cells attractive candidates for immunotherapeutic agents targeting MHC-I-deficient cancer stem cells in heterogeneous PDACs, little is known about PDAC stem cell immunology. In our study, PDAC-specific datasets from public databases were collected for in-depth bioinformatic analysis. We found that the abundance of PDAC stemness negatively influenced the infiltration of NK cells and identified the transcription factor ONECUT3 enriched in PDACs with high stemness index scores and Pan-cancer Stemness Signature levels. A series of NK cell-targeted inhibitory immune checkpoints were highly expressed in ONECUT3high PDACs. The patient group with high levels of ONECUT3 expression had a high risk of poor overall survival, even if accompanied by high infiltration of NK cells. Furthermore, the prostanoid metabolic process was enriched in ONECUT3high PDACs with high levels of NK cell-targeted inhibitory immune checkpoints. ONECUT3 enriched in high-stemness PDACs possessed the potential to transcriptionally regulate the prostanoid metabolism-related genes. Our study reveals ONECUT3 as a candidate stemness-related transcription factor regulating NK cell-targeted inhibitory immune checkpoints in PDAC. ONECUT3-mediated prostanoid metabolism may regulate cancer stemness and immune evasion in PDAC. Synergistic inhibition of prostanoid metabolism may improve the efficacy of NK cell-based immunotherapies targeting intratumoral heterogeneity caused by PDAC stem cells.

Finite Element Analysis of Dynamic Recrystallization Model and Microstructural Evolution for GCr15 Bearing Steel Warm-Hot Deformation Process.

Warm deformation is a plastic-forming process that differs from traditional cold and hot forming techniques. At the macro level, it can effectively reduce the problem of high deformation resistance in cold deformation and improve the surface decarburization issues during the hot deformation process. Microscopically, it has significant advantages in controlling product structure, refining grain size, and enhancing product mechanical properties. The Gleeble-1500D thermal-mechanical physical simulation system was used to conduct isothermal compression tests on GCr15 bearing steel. The tests were conducted at temperatures of 600-1050 °C and strain rates of 0.01-5 s-1. Based on the experimental data, the critical strain model and dynamic recrystallization model for the warm-hot forming of GCr15 bearing steel were established in this paper. The model accuracy is evaluated using statistical indicators such as the correlation coefficient (R). The dynamic recrystallization model exhibits high predictive accuracy, as indicated by an R-value of 0.986. The established dynamic recrystallization model for GCr15 bearing steel was integrated into the Forge® 3.2 numerical simulation software through secondary program development to simulate the compression process of GCr15 warm-hot forming. The dynamic recrystallization fraction was analyzed in various deformation regions. The grain size of the severe deformation zone, small deformation zone, and difficult deformation zone was compared based on simulated compression specimens under the conditions of 1050 °C and 0.1 s-1 with the corresponding grain size obtained with measurement based on metallographic photos; the relative error between the two is 5.75%. This verifies the accuracy of the established dynamic recrystallization and critical strain models for warm-hot deformation of GCr15 bearing steel. These models provide a theoretical basis for the finite element method analysis and microstructure control of the warm-hot forming process in bearing races.

Down-regulated Circ_0000190 promotes cervical cancer by facilitating the activity of proto-oncogene protein EIF4E.

Circular RNAs (circRNAs), a new class of non-coding RNAs, have been recently confirmed to regulate cell development, functions and certain types of pathological responses. In addition, it has been proved that circ_0000190 can serve as a tumor suppressor in several cancers. However, the underlying mechanism and biological functions of it in cervical cancer (CC) remain to be revealed. In our study, relative expression of indicated molecules was detected by RT-qPCR analysis. Loss-of-function and gain-of-function experiments were conducted to detect cell functions. Mechanism experiments including RIP assay, luciferase reporter assay and pull down assay were applied to verify the interaction among the indicated molecules. Overexpressed circ_0000190 attenuated CC progression in vitro and in vivo. Circ_0000190 functioned through the modulation of miR-1252-5p/EIF4EBP2 axis. Rescue experiments found that miR-1252-5p overexpression or EIF4EBP2 knockdown could reverse the influence on CC cells caused by circ_0000190 overexpression. Interestingly, it was found that EIF4EBP2 could bind to proto-oncogene eIF4E and prevent eIF4E from forming into complex and functioning. Circ_0000190 served as a tumor suppressor in CC and down-regulated circ_0000190 expression could weaken the binding ability of EIF4EBP2 to eIF4E thus leading to CC tumorigenesis. In our investigation, a novel tumor suppressive gene circ_0000190 was recognized, which could be treated as a promising biomarker for the diagnosis of CC.