Characterization and significance of localized sources identified by a novel automated algorithm during mapping of human persistent atrial fibrillation.

BACKGROUND: Automated algorithms may identify focal (FA) and rotational (RoA) activations during persistent atrial fibrillation (PeAF). OBJECTIVE: To evaluate an automated algorithm for characterizing and assessing significance of FA/RoA. METHODS: Eighty-six PeAF ablation patients (1411 maps) were analyzed. Maps were obtained with a 64-electrode basket using CARTOFINDER, which filters/annotates atrial unipolar electrograms over 30 seconds. Operators ablated FA/RoA followed by pulmonary vein isolation (PVI). The automated algorithm was retrospectively applied using QS patterns to identify FA and sequential activation gradients for RoA without phase mapping. Algorithm-identified FA and RoA were validated against blinded adjudicators. Ablation of algorithm-identified FA/RoA was related to procedural AF termination. RESULTS: 73% ± 18% of electrodes (65% ± 11% atrial surface area) were adequate for analysis. Compared with adjudicators, the algorithm had a sensitivity of 84% for FA and 86% for RoA. There were 4 ± 2 FA and 2 ± 2 RoA per patient. FA occurred 8 ± 6 times during the 30-second window (cumulative duration 8 ± 6 seconds). RoA occurred 5 ± 3 times (median 2, consecutive rotations) with a cumulative duration of 3 ± 2 seconds. Compared to patients without procedural AF termination, patients with termination had more FA ablated (75% vs 38%, P = 0.006). AF termination was not predicted by percentage of RoA ablated although there was a trend towards a higher percentage of left atrial RoA ablated ( P = 0.06). CONCLUSION: An automated algorithm had high sensitivity for FA and RoA. Acute AF termination was associated with FA ablation but not RoA ablation. Future studies need to define the significance of FA and RoA and whether they are overlapping or separate mechanisms.

Suppression of stimulated Brillouin scattering in optical fibers using a linearly chirped diode laser.

The output of high power fiber amplifiers is typically limited by stimulated Brillouin scattering (SBS). An analysis of SBS with a chirped pump laser indicates that a chirp of 2.5 × 10(15) Hz/s could raise, by an order of magnitude, the SBS threshold of a 20-m fiber. A diode laser with a constant output power and a linear chirp of 5 × 10(15) Hz/s has been previously demonstrated. In a low-power proof-of-concept experiment, the threshold for SBS in a 6-km fiber is increased by a factor of 100 with a chirp of 5 × 10(14) Hz/s. A linear chirp will enable straightforward coherent combination of multiple fiber amplifiers, with electronic compensation of path length differences on the order of 0.2 m.

Optical pulse propagation in the tight-binding approximation.

We formulate the equations describing pulse propagation in a one-dimensional optical structure described by the tight binding approximation, commonly used in solid-state physics to describe electrons levels in a periodic potential. The analysis is carried out in a way that highlights the correspondence with the analysis of pulse propagation in a conventional waveguide. Explicit expressions for the pulse in the waveguide are derived and discussed in the context of the sampling theorems of finite-energy space and time signals.

Comparative study of air-core and coaxial Bragg fibers: single-mode transmission and dispersion characteristics.

Using an asymptotic formalism we developed in an earlier paper, we compare the dispersion properties of the air-core Bragg fiber with those of the coaxial Bragg fiber. In particular we are interested in the way the inner core of the coaxial fiber influence the dispersion relation. It is shown that, given appropriate structural parameters, large single-mode frequency windows with a zero-dispersion point can be achieved for the TM mode in coaxial fibers. We provide an intuitive interpretation based on perturbation analysis and the results of our asymptotic calculations are confirmed by Finite Difference Time Domain (FDTD) simulations.

Analysis of optical pulse propagation with two-by-two (ABCD) matrices.

We review and extend the analogies between Gaussian pulse propagation and Gaussian beam diffraction. In addition to the well-known parallels between pulse dispersion in optical fiber and cw beam diffraction in free space, we review temporal lenses as a way to describe nonlinearities in the propagation equations, and then introduce further concepts that permit the description of pulse evolution in more complicated systems. These include the temporal equivalent of a spherical dielectric interface, which is used by way of example to derive design parameters used in a recent dispersion-managed soliton transmission experiment. This formalism offers a quick, concise, and powerful approach to analyzing a variety of linear and nonlinear pulse propagation phenomena in optical fibers.

Optical pulse propagation and holographic storage in a coupled-resonator optical waveguide.

We propose a method of storage and reconstruction of a classical light pulse based on photorefractive holography in a coupled-resonator optical waveguide (CROW). Pulse propagation in a CROW is described in the context of the tight-binding approximation; the use of a CROW results in a large reduction of the group velocity, which is important for spatial compression of the optical pulses. Further, the efficiency of the photorefractive effect is enhanced in a CROW, enabling quasistatic holographic grating formation using much lower intensity optical pulses. We describe in detail the formation of a photorefractive index grating in a CROW via interference with a reference pulse and the subsequent holographic reconstruction of the signal pulse.

Analysis and verification of an analog VLSI incremental outer-product learning system.

An architecture is described for the microelectronic implementation of arbitrary outer-product learning rules in analog floating-gate CMOS matrix-vector multiplier networks. The weights are stored permanently on floating gates and are updated under uniform UV illumination with a general incremental analog four-quadrant outer-product learning scheme, performed locally on-chip by a single transistor per matrix element on average. From the mechanism of floating gate relaxation under UV radiation, the authors derive the learning parameters and their dependence on the illumination level and circuit parameters. It is shown that the weight increments consists of two parts: one term contains the outer product of two externally applied learning vectors; the other part represents a uniform weight decay, with time constant originating from the floating gate relaxation. The authors address the implementation of supervised and unsupervised learning algorithms with emphasis on the delta rule. Experimental results from a simple implementation of the delta rule on an 8x7 linear network are included.

Operator algebra for propagation problems involving phase conjugation and nonreciprocal elements.

A self-consistent formalism is developed for treating propagation of beams in situations which include phase conjugation and nonreciprocal elements. Two equivalent field representations, the rectangular polarization and the circular polarization representation, are considered, and the rules for transforming between them are derived. An example involving a proposed new current fiber sensor is analyzed using the formalism.

Imaging of coherent fields through lenslike systems.

I derive the imaging condition for the complex amplitude of a monochromatic field by a sequence of lens-like elements.

Frustration of Bragg reflection by cooperative dual-mode interference: a new mode of optical propagation.

A new optical mode of propagation is described, which is the natural eigenmode (supermode) of a fiber (or any optical waveguide) with two cospatial periodic gratings. The mode frustrates the backward Bragg scattering from the grating by destructive interference of its two constituent submodes (which are eigenmodes of a uniform waveguide). It can be used in a new type of spatial mode conversion in optical guides.