Efficacy of modified radical prostatectomy technique for recovery of urinary incontinence in high-grade prostate cancer.

BACKGROUND: This study was conducted to evaluate predictive factors of urinary continence recovery after radical prostatectomy (RP) for high-grade prostate cancer (PCa). METHODS: A total of 241 patients with high-grade (Gleason Score 8 or 9) PCa who underwent RP in a single Korean center between January 2011 and May 2018 were retrospectively reviewed. Urinary continence was defined as no pads use. Urinary continence was evaluated at 1, 3, 6, and 12 months after RP. Univariate and multivariate analyses were performed to determine the predictive factors of urinary continence recovery after RP. RESULTS: The mean age was 67.6±6.4 years, and the mean PSA was 18.7±21.1 ng/dL. A total of 197 (81.7%) patients underwent nerve-sparing RP, and 198 patients (82.2%) were continent 1 year after RP. Multivariate analysis showed that the age (odds ratio [OR]=1.091 [1.015-1.172], P=0.018), Body Mass Index (BMI) (OR=1.227 [1.057-1.424], P=0.007), and modified surgical technique (OR=0.109 [0.044-0.267], P<0.001) were independent factors for predicting urinary continence recovery after RP. CONCLUSIONS: Younger age, low BMI, and modified surgery were independent predictors of urinary continence recovery after RP in patients with high-grade PCa. These findings may help surgeons to give pre- and postoperative advice to patients with high-grade PCa about urinary continence recovery after RP.

Impact of a bladder cuff excision during radical nephroureterectomy on cancer specific survival in patients with upper tract urothelial cancer in Korea: a retrospective, multi-institutional study.

BACKGROUND: Radical nephroureterectomy (RNU) with bladder cuff excision (BCE) is the surgical principle adopted for the treatment of upper tract urothelial cancers (UTUCs). However, not all RNUs are performed with BCE. We quantified the prognostic impact of RNU with BCE on cancer-specific survival (CSS) in a large patient population. METHODS: In total, 505 patients with UTUC were enrolled from four different institutions. The clinicopathological parameters of patients who underwent RNU with and without BCE were compared. The Kaplan-Meier and multivariate Cox regression analyses were performed to assess the influence of BCE on CSS. RESULTS: In total, 60 (11.9%) patients had not undergone BCE during RNU. Compared to patients who underwent BCE, these patients were older and had more comorbidities. Patients with UTUC who had not undergone BCE were more likely to be associated with ≥pT3, margin positivity, and renal pelvis localization compared to patients who underwent BCE. Median follow-up periods were 30.5 months (range, 6-144 months). The Kaplan-Meier estimates revealed that BCE during RNU was not significantly associated with CSS in all UTUC patients and in the subgroup with renal pelvis localization; however, patients who underwent RNU without BCE had significantly worse CSS rates compared to patients who underwent RNU with BCE in the subgroup analysis of patients with ureteral cancer. Multivariate analysis identified BCE as an independent prognostic factor of CSS in patients with ureteral cancer. CONCLUSIONS: In the present study, RNU without BCE resulted in significantly worse CSS in ureteral cancer patients, which indicated that BCE should be mandatory in patients with ureteral cancer.