Understanding adjustment profiles among Mexican-origin adolescents over time: A focus on cultural risk and resilience factors.

This study used a three-wave longitudinal dataset to: identify adjustment profiles of U.S. Mexican-origin adolescents based on their physical, academic, and psychosocial health adjustment; track adjustment profile changes throughout adolescence; and examine the associations between cultural stressors, family obligation, and adjustment profile membership over time. Participants were 604 Mexican-origin adolescents (54% female, Mage = 12.41, SD = 0.97) in Texas (Wave 1: 2012-2015; Wave 2: 2013-2016; Wave 3: 2017-2020). Three concurrent profiles (Well-adjusted, Moderate, and Poorly-adjusted) emerged at each wave, whereas three transition profiles (Improved, Stable well-adjusted, and Overall poorly-adjusted) were identified across three waves. The results suggest that cultural stressors pose risks for Mexican-origin adolescents' adjustment, and family obligation values play a protective role in these associations.

Human α-defensin 5 suppressed colon cancer growth by targeting PI3K pathway.

Defensins are highly conserved antimicrobial peptides, which ubiquitously expressed in different species. In addition to the functions in host defense, their aberrant expression have also been documented in cancerous tissue including breast cancer, lung caner and renal carcinoma etc. Whereas, roles of Defensin Alpha 5 (DEFA5) in colon cancer has not been explored. Bioinformatic analysis was used to study the expression of DEFA5 and its correlation with clinical outcomes; Western blot, qPCR, Co-immunoprecipitation, xenograft models were used to the study the molecular mechanism. Decreased expression of DEFA5 at protein level was observed in colon tissues. Colon cancer cell lines proliferation and colony formation capacity were significantly suppressed by DEFA5 overexpression. Moreover, in vivo tumor growth in nude mice was also suppressed by DEFA5 overexpression, suggesting a tumor suppressor role of DEFA5 in colon cancer. Mechanistically, DEFA5 directly binds to the subunits of PI3K complex, thus attenuates the downstream signaling transduction, leads to delayed cell growth and metastasis. Collectively, we concluded that DEFA5 showed an inhibitory effect in colon cancer cell growth and may serve as a potential tumor suppressor in colon cancer.

Mexican-origin youths' language brokering for fathers and mothers: Daily experiences and youths' diurnal cortisol slopes.

This study examined the associations of language brokering stress intensity and exposure with Mexican-origin youths' cortisol responses when brokering for fathers and mothers, and the moderating role of youths' brokering efficacy in these relations. Participants were 289 adolescents (Mage  = 17.38, SD = .94, 52% girls) in immigrant families. When brokering for mothers, stress exposure was related to flatter (less healthy) same-day diurnal slopes in youth. When brokering for fathers, daily brokering efficacy buffered the detrimental link between stress intensity and youths' same-day cortisol slopes. When brokering for fathers/mothers, stress intensity and exposure were related to flatter (less healthy) next-day diurnal slopes. Although daily brokering stress can relate to youth physiologic functioning, feeling efficacious about brokering may buffer the negative ramifications of stress.

Longitudinal change in adolescent hope among recent immigrant Latinx adolescents: Links with adolescent and parent cultural stress, family functioning, emotional well-being, and behavioral health.

Adolescent hope can promote the emotional and behavioral well-being of Latinx families. Positive family functioning may foster adolescent hope, whereas cultural stress may compromise adolescent hope and well-being. We examined how adolescent hope changed over time, and whether cultural stress and family functioning predicted emotional and behavioral health via adolescent hope intercept and slope. Recent Latinx immigrant adolescents (Mage  = 14.51) and parents (Mage  = 41.09; N = 302; n = 150 from Los Angeles; n = 152 from Miami) completed measures of above constructs over 3 years (Summer 2010 to Spring 2013). Latent growth curve modeling indicated that adolescent hope increased over time. Higher cultural stress predicted lower initial hope. Higher family functioning predicted higher initial levels of and less steep increase in hope. Increase in hope predicted better emotional and behavioral health. Family functioning predicted better health outcomes by way of hope.

RETRACTED ARTICLE: Ultrasound microbubble-mediated miR-150-5p inhibits gastric cancer cell growth by targeting the expression of NR2F2.

We, the Editor and Publisher of the Journal of Receptors and Signal Transduction, have retracted the following article: Ultrasound microbubble-mediated miR-150-5p inhibits gastric cancer cell growth by targeting the expression of NR2F2; Wei Wei, Xiaoguang Wei, Minyu Zhang & Cheng Peng; https://doi/10.1080/10799893.2021.1884260Since publication, concerns have been raised about the integrity of the following figures in the article. 2(A) miR-NC and 2(D) miR-NC-MBs;2(A) Control and 5(C) NR2F2-MBs + miR-NC-MBsWhen approached for an explanation, the authors were unable to provide original data in a suitable format that would confirm the authenticity of the data. The authors have been notified of the retraction but have not responded.We have been informed in our decision-making by our policy on publishing ethics and integrity and the COPE guidelines on retractions.The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as 'Retracted'.

Combining data augmentation and domain information with TENER model for Clinical Event Detection.

BACKGROUND: In recent years, with the development of artificial intelligence, the use of deep learning technology for clinical information extraction has become a new trend. Clinical Event Detection (CED) as its subtask has attracted the attention from academia and industry. However, directly applying the advancements in deep learning to CED task often yields unsatisfactory results. The main reasons are due to the following two points: (1) A great number of obscure professional terms in the electronic medical record leads to poor recognition performance of model. (2) The scarcity of datasets required for the task leads to poor model robustness. Therefore, it is urgent to solve these two problems to improve model performance. METHODS: This paper proposes a combining data augmentation and domain information with TENER Model for Clinical Event Detection. RESULTS: We use two evaluation metrics to compare the overall performance of the proposed model with the existing model on the 2012 i2b2 challenge dataset. Experimental results demonstrate that our proposed model achieves the best F1-score of 80.26%, type accuracy of 93% and Span F1-score of 90.33%, and outperforms the state-of-the-art approaches. CONCLUSIONS: This paper proposes a multi-granularity information fusion encoder-decoder framework, which applies the TENER model to the CED task for the first time. It uses the pre-trained language model (BioBERT) to generate word-level features, solving the problem of a great number of obscure professional terms in the electronic medical record lead to poor recognition performance of model. In addition, this paper proposes a new data augmentation method for sequence labeling tasks, solving the problem of the scarcity of datasets required for the task leads to poor model robustness.

Signature-oriented investigation of the efficacy of multicomponent drugs against heart failure.

Increasing attention has been paid to the application of precision medicine in heart failure (HF), and biomarker-based personalized medical care has shown great progress in HF management. Additionally, multicomponent drugs represented by traditional Chinese medicine (TCM) are demonstrating safety and efficacy in the management of HF. However, the potential mechanism is unclear, and the ambiguous clinical locations of TCM remain a hindrance to its extensive application. To meet this requirement, a precise investigation on the efficacy of multicomponent drugs against HF using the signature biomarkers-oriented approach was developed and applied to a conventional drug for cardiac disease, YiXinShu (YXS). On the basis of in vitro and in vivo efficacy evaluation of YXS against HF, and with the aid of proteomics and network pharmacology approaches, specific signatures regulated by YXS against HF were identified. YXS may show distinctive treatment features for those HF patients showing the elevation of fatty acid-binding protein 3 and cytoskeleton-associated protein 5, as well as other classic HF biomarkers. This study provides the first precise investigation of the efficacy of multicomponent drugs against HF and offers a practicable and low-cost approach for personalized management of HF.-Wei, J., Guo, F., Zhang, M., Xian, M., Wang, T., Gao, J., Wu, H., Song, L., Zhang, Y., Li, D., Yang, H., Huang, L. Signature-oriented investigation of the efficacy of multicomponent drugs against heart failure.

Enhanced character-level deep convolutional neural networks for cardiovascular disease prediction.

BACKGROUND: Electronic medical records contain a variety of valuable medical information for patients. So, when we are able to recognize and extract risk factors for disease from EMRs of patients with cardiovascular disease (CVD), and are able to use them to predict CVD, we have the ability to automatically process clinical texts, resulting in an improved accuracy of supporting doctors for the clinical diagnosis of CVD. In the case where CVD is becoming more worldwide, predictive CVD based on EMRs has been studied by many researchers to address this important aspect of improving diagnostic efficiency. METHODS: This paper proposes an Enhanced Character-level Deep Convolutional Neural Networks (EnDCNN) model for cardiovascular disease prediction. RESULTS: On the manually annotated Chinese EMRs corpus, our risk factor identification extraction model achieved 0.9073 of F-score, our prediction model achieved 0.9516 of F-score, and the prediction result is better than the most previous methods. CONCLUSIONS: The character-level model based on text region embedding can well map risk factors and their labels as a unit into a vector, and downsampling plays a crucial role in improving the training efficiency of deep CNN. What's more, the shortcut connections with pre-activation used in our model architecture implements dimension-matching free in training.

Parent-Adolescent Acculturation Profiles and Adolescent Language Brokering Experiences in Mexican Immigrant Families.

Language brokering is a special form of interpersonal communication that is affected by the cultural and relational settings in which it occurs. The current study explores whether parent-adolescent acculturation status may influence Mexican American adolescent language brokers' translation experiences, including brokering frequency and attitudes. Using data from a two-wave longitudinal study (Nwave1 = 604; Nwave2 = 483; Mwave1.age = 12.91; 54.3% female), latent profile analyses were conducted, resulting in four mother-adolescent acculturation profiles as well as three father-adolescent profiles. The adolescent integrated-parent (moderately) separated profiles emerged as the most effective for brokers, as adolescents in this profile generally experienced more positive and less negative brokering attitudes, regardless of their brokering frequency. Parent-adolescent acculturation profiles may be a useful construct in capturing the interplay of cultural and relational settings and their effects on multifaceted language brokering experiences.

Measurement invariance of language brokering extent and attitudes in linguistic minority adolescents: Item response theory analyses.

OBJECTIVE: Using item response theory, we sought to evaluate measurement invariance of language brokering extent and attitudes in 3 linguistic minority groups of adolescents. METHOD: The sample included 765 (302 Chinese American, 327 Korean American, and 136 Mexican American; 57% females) ninth graders from immigrant families. RESULTS: Differential item functioning was detected for several items, and we retained items with equivalent parameters across 3 groups. The final items showed adequate internal consistency reliability and criterion validity. CONCLUSION: The refined scale is cross-ethnically invariant and appropriate for use with Chinese-American, Korean-American, and Mexican-American adolescents to compare their language brokering experiences. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Parenting and Centrality: The Role of Life Meaning as a Mediator for Parenting and Language Broker Role Identity.

Language brokering is a prevalent phenomenon in ethnic minority immigrant populations. Although accruing evidence points to the beneficial impacts of healthy role identity development, research investigating the formation of a language broker role identity in language brokering adolescents is lacking in the literature. In a sample of 604 Latinx adolescents (54.3% female; Mage at Time 1 = 12.41, SD = .97), structured equation modeling was conducted with maternal warmth and hostility examined as antecedents and adolescents' life meaning as a mediator for language broker role identities. Results revealed that life meaning mediated the positive association from maternal warmth to language broker role identity. However, the negative association from maternal hostility to language broker role identity was no longer significant when accounting for maternal warmth. Corroborating extant findings, reciprocal relations were observed between maternal parenting practices, life meaning and language broker role identity. The results attest to the importance of investigating culturally specific role identity development in immigrant populations and demonstrates the role of maternal parenting practices in affecting adolescents' role identity formation, albeit with contrasting gender effects.

Acute salivary cortisol response among Mexican American adolescents in immigrant families.

OBJECTIVES: Though previous research has indicated that language brokering can be stressful, the findings are mixed, pointing to potential moderators of the association. Guided by an ecological perspective, we examined the role of individual, family, and environmental factors in Mexican American adolescents' acute cortisol responses to language brokering. METHOD: The study consisted of 46 Mexican American adolescents recruited around a metropolitan city in Central Texas. Participants translated a difficult medical document from English to Spanish for their parents, followed by an arithmetic task (modeled after the Trier Social Stress Test [TSST]). Participants' perceptions (perceived efficacy and parental dependence), parental hostility, and discrimination experiences were assessed via self-report and were examined as moderators of adolescents' responses to the task. RESULTS: Results revealed differential responses to the task based on individual, family, and environmental factors. High efficacy and low dependence-parental hostility-discrimination related to stress responses characterized by low baselines, steeper reactivity, and faster recovery. Low efficacy and high dependence related to greater baseline stress and a slower recovery. High levels of parental hostility related to a slower recovery. High levels of discrimination related to greater baseline stress. CONCLUSIONS: The study demonstrates that the modified TSST task can elicit an acute hypothalamic-pituitary-adrenal axis response, but the nature of this response is dependent upon participants' perceptions of language brokering (parental dependence and efficacy), parental hostility, and discrimination experiences. Adolescents' individual characteristics and contextual demands remain important considerations in understanding their acute stress responses. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Schisandra chinensis Fructus and Its Active Ingredients as Promising Resources for the Treatment of Neurological Diseases.

Neurological diseases (NDs) are a leading cause of death worldwide and tend to mainly affect people under the age of 50. High rates of premature death and disability caused by NDs undoubtedly constrain societal development. However, effective therapeutic drugs and methods are very limited. Schisandra chinensis Fructus (SCF) is the dry ripe fruit of Schisandra chinensis (Turcz.) Baill, which has been used in traditional Chinese medicine for thousands of years. Recent research has indicated that SCF and its active ingredients show a protective role in NDs, including cerebrovascular diseases, neurodegenerative diseases, or depression. The key neuroprotective mechanisms of SCF and its active ingredients have been demonstrated to include antioxidation, suppression of apoptosis, anti-inflammation, regulation of neurotransmitters, and modulation of brain-derived neurotrophic factor (BDNF) related pathways. This paper summarizes studies of the role of SCF and its active ingredients in protecting against NDs, and highlights them as promising resources for future treatment. Furthermore, novel insights on the future challenges of SCF and its active ingredients are offered.

Profiles of Language Brokering Experiences and Contextual Stressors: Implications for Adolescent Outcomes in Mexican Immigrant Families.

Adolescents from Mexican immigrant families are often embedded in a challenging social environment and experience multiple contextual stressors, including economic stress, discrimination, and foreigner stress. We consider how the effects of these contextual stressors may be amplified or diminished for adolescents who function as language brokers, interpreting and mediating for their English-limited parents. Using two waves of survey data collected from a sample (N = 604 at Wave 1; N = 483 at Wave 2) of Mexican American adolescents with ages ranging from 11 to 15 (Mage = 12.41, 54% female), four distinct brokering-stress profiles were identified. Latent profile analyses revealed that with moderate levels of contextual stress, adolescents with more positive language brokering experiences (protective group) demonstrated more favorable outcomes than those with neutral language brokering experiences (moderate group) and those who did not involve themselves as frequently in language brokering activities (less-involved group). In contrast, high levels of contextual stress, coupled with more negative language brokering experiences (risk group), produced the least favorable outcomes among adolescents.

[Pharmacological effect of Schisandrae Chinensis Fructus and relative active components on cardiovascular and cerebrovascular diseases].

Cardiovascular and cerebrovascular diseases (CCDs) are the primary causes of death in Chinese adults. With the increase in morbidity and mortality rates and the decrease in the age of onset, CCD becomes a very natural target for traditional Chinese medicine. Schisandrae Chinensis Fructus (SCF) is the dry ripe fruit of Schisandra chinensis (Turcz.) Baill., which features a sweet and sour taste and the effects of calming the heart and tranquilizing the mind. It is mainly used for treatment of dysphoria and palpitation, insomnia and dreamful sleep due to the lack of spirit preservation. The main components of SC include lignans, volatile oils and polysaccharides. This review summarized the pharmacological effects of SC and its active components in the treatment of CCDs. The results showed that SCF and its active components protect against cardiovascular diseases mainly through the antioxidant, apoptosis inhibition and anti-inflammatory mechanisms. In addition, they protect against cerebrovascular diseases mainly by increasing energy metabolism, regulating autophagy and inhibiting apoptosis, antioxidant, and regulating nerve neurotransmitters and circadian genes. In conclusion, lignans are the most active components in SCF. This study provides a reference for the clinical research and utilization of SCF, as well as the application basis for co-treatment of cardiovascular and cerebrovascular diseases.

Longitudinal measurement equivalence of subjective language brokering experiences scale in Mexican American adolescents.

OBJECTIVE: Language brokering occurs frequently in immigrant families and can have significant implications for the well-being of family members involved. The present study aimed to develop and validate a measure that can be used to assess multiple dimensions of subjective language brokering experiences among Mexican American adolescents. METHOD: Participants were 557 adolescent language brokers (54.2% female, Mage.wave1 = 12.96, SD = .94) in Mexican American families. RESULTS: Using exploratory and confirmatory factor analyses, we were able to identify 7 reliable subscales of language brokering: linguistic benefits, socioemotional benefits, efficacy, positive parent-child relationships, parental dependence, negative feelings, and centrality. Tests of factorial invariance show that these subscales demonstrate, at minimum, partial strict invariance across time and across experiences of translating for mothers and fathers, and in most cases, also across adolescent gender, nativity, and translation frequency. Thus, in general, the means of the subscales and the relations among the subscales with other variables can be compared across these different occasions and groups. Tests of criterion-related validity demonstrated that these subscales correlated, concurrently and longitudinally, with parental warmth and hostility, parent-child alienation, adolescent family obligation, depressive symptoms, resilience, and life meaning. CONCLUSION: This reliable and valid subjective language brokering experiences scale will be helpful for gaining a better understanding of adolescents' language brokering experiences with their mothers and fathers, and how such experiences may influence their development. (PsycINFO Database Record

Physical exercise plays a role in rebalancing the bile acids of enterohepatic axis in non-alcoholic fatty liver disease.

Non-alcoholic fatty liver disease (NAFLD) is considered as one of the most common diseases of lipid metabolism disorders, which is closely related to bile acids disorders and gut microbiota disorders. Bile acids are synthesized from cholesterol in the liver, and processed by gut microbiota in intestinal tract, and participate in metabolic regulation through the enterohepatic circulation. Bile acids not only promote the consumption and absorption of intestinal fat but also play an important role in biological metabolic signaling network, affecting fat metabolism and glucose metabolism. Studies have demonstrated that exercise plays an important role in regulating the composition and function of bile acid pool in enterohepatic axis, which maintains the homeostasis of the enterohepatic circulation and the health of the host gut microbiota. Exercise has been recommended by several health guidelines as the first-line intervention for patients with NAFLD. Can exercise alter bile acids through the microbiota in the enterohepatic axis? If so, regulating bile acids through exercise may be a promising treatment strategy for NAFLD. However, the specific mechanisms underlying this potential connection are largely unknown. Therefore, in this review, we tried to review the relationship among NAFLD, physical exercise, bile acids, and gut microbiota through the existing data and literature, highlighting the role of physical exercise in rebalancing bile acid and microbial dysbiosis.

Analysis of quality of life in patients after transgastric natural orifice transluminal endoscopic gallbladder-preserving surgery.

BACKGROUND: At present, laparoscopic cholecystectomy (LC) is the main surgical treatment for gallstones. But, after gallbladder removal, there are many complications. Therefore, it is hoped to remove stones while preserving the function of the gallbladder, and with the development of endoscopic technology, natural orifice transluminal endoscopic surgery came into being. AIM: To compare the quality of life, perioperative indicators, adverse events after LC and transgastric natural orifice transluminal endoscopic gallbladder-preserving surgery (EGPS) in patients with gallstones. METHODS: Patients who were admitted to The First Affiliated Hospital of Xinjiang Medical University from 2020 to 2022 were retrospectively collected. We adopted propensity score matching (1:1) to compare EGPS and LC patients. RESULTS: A total of 662 cases were collected, of which 589 cases underwent LC, and 73 cases underwent EGPS. Propensity score matching was performed, and 40 patients were included in each of the groups. In the EGPS group, except the gastrointestinal defecation (P = 0.603), the total score, physical well-being, mental well-being, and gastrointestinal digestion were statistically significant compared with the preoperative score after surgery (P < 0.05). In the LC group, except the mental well-being, the total score, physical well-being, gastrointestinal digestion, the gastrointestinal defecation was statistically significant compared with the preoperative score after surgery (P < 0.05). When comparing between groups, gastrointestinal defecation had significantly difference (P = 0.002) between the two groups, there was no statistically significant difference in the total postoperative score and the other three subscales. In the surgery duration, hospital stay and cost, LC group were lower than EGPS group. The recurrence factors of gallstones after EGPS were analyzed: and recurrence was not correlated with gender, age, body mass index, number of stones, and preoperative score. CONCLUSION: Whether EGPS or LC, it can improve the patient's symptoms, and the EGPS has less impact on the patient's defecation. It needed to, prospective, multicenter, long-term follow-up, large-sample related studies to prove.

Overview of Panax ginseng and its active ingredients protective mechanism on cardiovascular diseases.

ETHNIC PHARMACOLOGICAL RELEVANCE: Panax ginseng is a traditional Chinese herbal medicine used to treat cardiovascular diseases (CVDs), and it is still widely used to improve the clinical symptoms of various CVDs. However, there is currently a lack of summary and analysis on the mechanism of Panax ginseng exerts its cardiovascular protective effects. This article provides a review of in vivo and in vitro pharmacological studies on Panax ginseng and its active ingredients in reducing CVDs damage. AIM OF THIS REVIEW: This review summarized the latest literature on Panax ginseng and its active ingredients in CVDs research, aiming to have a comprehensive and in-depth understanding of the cardiovascular protection mechanism of Panax ginseng, and to provide new ideas for the treatment of CVDs, as well as to optimize the clinical application of Panax ginseng. METHODS: Enrichment of pathways and biological terms using the traditional Chinese medicine molecular mechanism bioinformatics analysis tool (BATMAN-TCM). The literature search is based on electronic databases such as PubMed, ScienceDirect, Scopus, CNKI, with a search period of 2002-2023. The search terms include Panax ginseng, Panax ginseng ingredients, ginsenosides, ginseng polysaccharides, ginseng glycoproteins, ginseng volatile oil, CVDs, heart, and cardiac. RESULTS: 132 articles were ultimately included in the review. The ingredients in Panax ginseng that manifested cardiovascular protective effects are mainly ginsenosides (especially ginsenoside Rb1). Ginsenosides protected against CVDs such as ischemic reperfusion injury, atherosclerosis and heart failure mainly through improving energy metabolism, inhibiting hyper-autophagy, antioxidant, anti-inflammatory and promoting secretion of exosomes. CONCLUSION: Panax ginseng and its active ingredients have a particularly prominent effect on improving myocardial energy metabolism remodeling in protecting against CVDs. The AMPK and PPAR signaling pathways are the key targets through which Panax ginseng produces multiple mechanisms of cardiovascular protection. Extracellular vesicles and nanoparticles as carriers are potential delivery ways for optimizing the bioavailability of Panax ginseng and its active ingredients.

Human ß-defensin-1 affects the mammalian target of rapamycin pathway and autophagy in colon cancer cells through long non-coding RNA TCONS_00014506.

BACKGROUND: Colorectal cancer has a low 5-year survival rate and high mortality. Human ß-defensin-1 (hBD-1) may play an integral function in the innate immune system, contributing to the recognition and destruction of cancer cells. Long non-coding RNAs (lncRNAs) are involved in the process of cell differentiation and growth. AIM: To investigate the effect of hBD-1 on the mammalian target of rapamycin (mTOR) pathway and autophagy in human colon cancer SW620 cells. METHODS: CCK8 assay was utilized for the detection of cell proliferation and determination of the optimal drug concentration. Colony formation assay was employed to assess the effect of hBD-1 on SW620 cell proliferation. Bioinformatics was used to screen potentially biologically significant lncRNAs related to the mTOR pathway. Additionally, p-mTOR (Ser2448), Beclin1, and LC3II/I expression levels in SW620 cells were assessed through Western blot analysis. RESULTS: hBD-1 inhibited the proliferative ability of SW620 cells, as evidenced by the reduction in the colony formation capacity of SW620 cells upon exposure to hBD-1. hBD-1 decreased the expression of p-mTOR (Ser2448) protein and increased the expression of Beclin1 and LC3II/I protein. Furthermore, bioinformatics analysis identified seven lncRNAs (2 upregulated and 5 downregulated) related to the mTOR pathway. The lncRNA TCONS_00014506 was ultimately selected. Following the inhibition of the lncRNA TCONS_00014506, exposure to hBD-1 inhibited p-mTOR (Ser2448) and promoted Beclin1 and LC3II/I protein expression. CONCLUSION: hBD-1 inhibits the mTOR pathway and promotes autophagy by upregulating the expression of the lncRNA TCONS_00014506 in SW620 cells.