The union of anti-CD34 antibody can improve the performance of drug-eluting stents.

OBJECTIVES: The authors investigate whether the combination of anti-CD34 antibody with DES is win-win cooperation. BACKGROUND: DES may reduce the risk of restenosis compared to bare-metal stents (BMS), but they were found to inhibit the healing process of intima. METHODS: Fifteen BMS, 17 DES, and 16 combined anti-CD34 antibody and DES were randomly implanted in the coronary arteries of 22 minipigs. Ten minipigs were followed up to 2 weeks. The stenting coronary segments were examined by histological examination and scanning electron microscopy after in vivo coronary angiography and intracoronary optical coherence tomography (OCT) examinations. The other 12 minipigs were followed up to 3 months. Coronary angiography and intracoronary OCT examination were performed in vivo and histological examination was performed on the stenting coronary segments. RESULTS: After 2 weeks, the neointimal covering level of the DES was lower than that in BMS, but the covering level of the combined stents was even better than the BMS. After 3 months, neointimal hyperplasia was significant in the BMS, but not in the other two types of stents. The in-stent late lumen loss of the combined stents even showed a decreasing tendency when compared with the DES. CONCLUSION: The combination of anti-CD34 antibody and DES can not only well offset the short-term inhibitory effect on re-endothelialization but also slightly enhance the long-term antiproliferative effect.

[The research actualities of drug eluting-stents and the developing trend].

The development of drug eluting-stents has been a breakthrough for the prevention of PCI postoperative restenosis, and the correlative researches have not yet stopped and are still the focus of the world. We review, in this article, the history of drug eluting-stents researches, analyze the research actualities and the problems existing, and forecast the developing trend in the future.

[Effect of dust deposition collection methods on collection efficiency].

There are lots of dust deposition collection methods on dust deposition, but there is no standard field observation method. At present, researchers have studied dust deposition using different methods in this issue, but due to the different observation method and collection efficiency, the research results are incomparable. The efficiency of the standard dust deposition gauge including dry, wet, net, net and glass ball and slowing speed methods was studied in the Tengger Desert. The amount of the dry method collected material was only about 5% to 62% of the wet method, the net method was only about 43% to 89% of the wet method, the net and glass ball method was only about 40% to 80% of the wet method. Wind speed obviously affected the dust deposition efficiency in all observation methods, the dust deposition efficiency decreased with increasing wind speed when the wind speed was smaller than 2.5 m.s-1, but the dust deposition efficiency had no clear trend with wind speed when the wind speed was larger than 2.5 m.s-1. The particle size of collected material by wet method was the smallest, followed by the slowing speed method, the net and glass ball method, the wet method and the dry method. There are relationships between the averaged wind speed, the averaged larger than 5 m.s-1 wind speed and the amount of dust deposition collected by the wet and the slowing speed methods, which can be expressed as exponential function. There are also linear relationships between the amount of collected material by the wet and dry, net, net and glass ball and slowing speed methods. The wet method is the best dust deposition collecting method, followed by the slow wind speed method. Therefore, in the arid and semi-arid regions, the slowing wind speed method can be used to replace the wet method to collect dust deposition.