1.
Org Biomol Chem
; 22(6): 1299-1309, 2024 Feb 07.
Artículo
en Inglés
| MEDLINE
| ID: mdl-38259138
RESUMEN
A copper-catalyzed aerobic oxidative cross-dehydrogenative coupling reaction between secondary amides and terminal alkynes has been developed. With the aid of ligands and 3 Å molecular sieves, ynamides can be efficiently synthesized at room temperature and conveniently scaled up. A legitimate mechanism involving nitrogen-centred radicals and copper trivalent intermediates has been proposed.