Green tea supplementation promotes leukocyte telomere length elongation in obese women / La suplementación con té verde promueve la elongación de los telómeros de leucocitos en mujeres obesas
Nutr. hosp
; 35(3): 570-575, mayo-jun. 2018. graf, tab
Article
en En
| IBECS
| ID: ibc-180113
Biblioteca responsable:
ES1.1
Ubicación: BNCS
RESUMEN
Introduction: inflammation and oxidative stress are factors that may play a substantial role in telomere attrition. In line of this, obesity is associated with telomere shortening. Green tea had anti-inflammatory and antioxidant effects and may alter telomere length (TL).Objectives: we evaluated the effect of decaffeinated green tea supplementation in obese women on TL. Methods: we conducted a cross-sectional interventional study with ten obese (body mass index [BMI] > 40 kg/m²) and eight normal weight (BMI > 18.5 and < 24.9 kg/m²) women (age between 27 and 48 years). The supplementation was carried out with capsules (each contained 450.7 mg of epigallocatechin-3-gallate) during eight weeks. Anthropometric and dietary intake assessment, and blood collection (for biochemical and TL analysis by quantitative PCR) were performed before and after supplementation. Normal weight patients were evaluated at a single moment. Results: we observed a significant increase on TL after supplementation (1.57 ± 1.1 to 3.2 ± 2.1 T/Sratio; p < 0.05). Moreover, we found shorter TL in obese patients (day 0) when compared to normal weight individuals (3.2 ± 1.9 T/Sratio; p < 0.05) and an inverse association between TL and BMI, even after age adjustment (beta = -0.527; r² = 0.286; IC = -0.129, -0.009).Conclusion: obesity is related to shorter telomeres. Green tea supplementation during eight weeks promotes telomere elongation in obese women
Texto completo:
1
Colección:
06-national
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ES
Banco de datos:
IBECS
Asunto principal:
Té
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Catequina
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Telómero
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Suplementos Dietéticos
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Leucocitos
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Obesidad
Límite:
Adult
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Female
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Humans
Idioma:
En
Revista:
Nutr. hosp
Año:
2018
Tipo del documento:
Article