Trends of incidence, mortality and survival of multiple myeloma in Spain. A twenty-three-year population-based study
Clin. transl. oncol. (Print)
; 23(7): 1429-1439, jul. 2021. graf
Article
en En
| IBECS
| ID: ibc-221983
Biblioteca responsable:
ES1.1
Ubicación: ES15.1 - BNCS
ABSTRACT
Background Despite major advances, multiple myeloma remains an incurable disease. Epidemiological data from high-quality population-based registries are needed to understand the heterogeneous landscape of the disease. Methods Incidence, mortality and survival in multiple myeloma were comprehensively analyzed in the Girona and Granada population-based cancer registries, over a 23-year study (19942016), divided into three periods (19942001, 20022009 and 20102016). Joinpoint regression analysis was used to estimate the annual percentage change in incidence and mortality. Age-standardized net survival was calculated with the PoharPerme method. Results 1957 myeloma patients were included in the study, with a median age of 72 years. Age-standardized incidence and mortality rates decreased over time in both sexes and both rates were higher in males. Five-year age-standardized net survival by period was 27.4% (19942001), 38.8% (20022009), and 47.4% (20102016). Survival improved for all age groups: 32.4%, 74.1% and 78.5% for patients aged 1549; 27.5%, 44.6%, and 58.5% for those aged 5069; finally, 24.8%, 25.5%, and 26.3% for the older group. Conclusion Incidence remained overall stable throughout the study, with only a small increase for men. Mortality was progressively decreasing in both sexes. Both incidence and mortality were higher in men. Age plays a critical role in survival, with impressive improvement in patients younger than 70 years, but only a minor benefit in those older than 70 (AU)
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Colección:
06-national
/
ES
Banco de datos:
IBECS
Asunto principal:
Mieloma Múltiple
Límite:
Adolescent
/
Adult
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Aged
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Female
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Humans
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Male
País/Región como asunto:
Europa
Idioma:
En
Revista:
Clin. transl. oncol. (Print)
Año:
2021
Tipo del documento:
Article