Differential regulation of granuloma size and hepatic fibrosis in schistosome infections
Mem. Inst. Oswaldo Cruz
; 92(5): 689-92, Sept.-Oct. 1997. tab
Article
en En
| LILACS
| ID: lil-194217
Biblioteca responsable:
BR15.1
ABSTRACT
Granuloma size is the variable most frequently used to evaluate the immunopathogenesis of schistosome infections. However, hepatic fibrosis is at the least an equally relevant variable. Hepatic fibrosis and the size of circumoval granulomas are frequently dissociated in experimental murine Schistosoma mansoni and S. japonicum infections. Virtually nothing is known of the immunoregulation of schistosomal hepatic fibrosis. This review notes many of the studies which have found discrepancies in granuloma volume and hepatic fibrosis, attempts to put them in perspective and to evaluate methods of calculating changes in collagen synthesis or content.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
LILACS
Asunto principal:
Granuloma
/
Cirrosis Hepática
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Año:
1997
Tipo del documento:
Article