Organization and regulation of mitogen-activated protein kinase signaling pathways.
Curr Opin Cell Biol
; 11(2): 211-8, 1999 Apr.
Article
en En
| MEDLINE
| ID: mdl-10209154
ABSTRACT
Mitogen-activated protein kinases (MAPKs) are components of a three kinase regulatory cascade. There are multiple members of each component family of kinases in the MAPK module. Specificity of regulation is achieved by organization of MAPK modules, in part, by use of scaffolding and anchoring proteins. Scaffold proteins bring together specific kinases for selective activation, sequestration and localization of signaling complexes. The recent elucidation of scaffolding mechanisms for MAPK pathways has begun to solve the puzzle of how specificity in signaling can be achieved for each MAPK pathway in different cell types and in response to different stimuli. As new MAPK members are defined, determining their organization in kinase modules will be critical in understanding their select role in cellular regulation.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Transducción de Señal
/
Procesamiento Proteico-Postraduccional
/
Proteínas Quinasas Dependientes de Calcio-Calmodulina
/
Proteínas de Saccharomyces cerevisiae
/
Proteínas Adaptadoras Transductoras de Señales
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Cell Biol
Año:
1999
Tipo del documento:
Article
País de afiliación:
Estados Unidos