Negative regulation of airway responsiveness that is dependent on gammadelta T cells and independent of alphabeta T cells.
Nat Med
; 5(10): 1150-6, 1999 Oct.
Article
en En
| MEDLINE
| ID: mdl-10502818
ABSTRACT
The mechanisms regulating airway function are complex and still poorly understood. In diseases such as asthma, involvement of immune-dependent mechanisms has been suggested in causing changes in airway responsiveness to bronchoconstrictors. We now demonstrate that gammadelta T cells can regulate airway function in an alphabeta T cell-independent manner, identifying them as important cells in pulmonary homeostasis. This function of gammadelta T cells differs from previously described immune-dependent mechanisms and may reflect their interaction with innate systems of host defense.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Hipersensibilidad Respiratoria
/
Receptores de Antígenos de Linfocitos T gamma-delta
/
Receptores de Antígenos de Linfocitos T alfa-beta
Límite:
Animals
Idioma:
En
Revista:
Nat Med
Asunto de la revista:
BIOLOGIA MOLECULAR
/
MEDICINA
Año:
1999
Tipo del documento:
Article
País de afiliación:
Estados Unidos