An iron-regulated ferric reductase associated with the absorption of dietary iron.
Science
; 291(5509): 1755-9, 2001 Mar 02.
Article
en En
| MEDLINE
| ID: mdl-11230685
ABSTRACT
The ability of intestinal mucosa to absorb dietary ferric iron is attributed to the presence of a brush-border membrane reductase activity that displays adaptive responses to iron status. We have isolated a complementary DNA, Dcytb (for duodenal cytochrome b), which encoded a putative plasma membrane di-heme protein in mouse duodenal mucosa. Dcytb shared between 45 and 50% similarity to the cytochrome b561 family of plasma membrane reductases, was highly expressed in the brush-border membrane of duodenal enterocytes, and induced ferric reductase activity when expressed in Xenopus oocytes and cultured cells. Duodenal expression levels of Dcytb messenger RNA and protein were regulated by changes in physiological modulators of iron absorption. Thus, Dcytb provides an important element in the iron absorption pathway.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Oxidorreductasas
/
Compuestos Férricos
/
Transfección
/
Hierro de la Dieta
/
Grupo Citocromo b
/
Duodeno
/
Absorción Intestinal
/
Mucosa Intestinal
Tipo de estudio:
Risk_factors_studies
Idioma:
En
Revista:
Science
Año:
2001
Tipo del documento:
Article
País de afiliación:
Reino Unido