A CD14-independent LPS receptor cluster.
Nat Immunol
; 2(4): 338-45, 2001 Apr.
Article
en En
| MEDLINE
| ID: mdl-11276205
ABSTRACT
Bacterial lipopolysaccharide (LPS), the major structural component of the outer wall of Gram-negative bacteria, is a potent initiator of an inflammatory response and serves as an indicator of bacterial infection. Although CD14 has been identified as the main LPS receptor, accumulating evidence has suggested the possible existence of other functional receptor(s). In this study, using affinity chromatography, peptide mass fingerprinting and fluorescence resonance energy transfer, we have identified four new proteins that form an activation cluster after LPS ligation and are involved in LPS signal transduction. Here we present evidence that implicates heat shock proteins 70 and 90, chemokine receptor 4 and growth differentiation factor 5 as the main mediators of activation by bacterial lipopolysaccharide.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Receptores de Lipopolisacáridos
/
Proteínas Morfogenéticas Óseas
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Reino Unido