Microbial pathway engineering for industrial processes: evolution, combinatorial biosynthesis and rational design.
Curr Opin Microbiol
; 4(3): 330-5, 2001 Jun.
Article
en En
| MEDLINE
| ID: mdl-11378488
ABSTRACT
Microbial pathway engineering has made significant progress in multiple areas. Many examples of successful pathway engineering for specialty and fine chemicals have been reported in the past two years. Novel carotenoids and polyketides have been synthesized using molecular evolution and combinatorial strategies. In addition, rational design approaches based on metabolic control have been reported to increase metabolic flux to specific products. Experimental and computational tools have been developed to aid in design, reconstruction and analysis of non-native pathways. It is expected that a hybrid of evolutionary, combinatorial and rational design approaches will yield significant advances in the near future.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Microbiología Industrial
Idioma:
En
Revista:
Curr Opin Microbiol
Asunto de la revista:
MICROBIOLOGIA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos