Post-traumatic stress disorder: a review of psychobiology and pharmacotherapy.
Acta Psychiatr Scand
; 104(6): 411-22, 2001 Dec.
Article
en En
| MEDLINE
| ID: mdl-11782234
ABSTRACT
OBJECTIVE:
To review the literature on the psychobiology and pharmacotherapy of PTSD.METHODS:
Relevant studies were identified by literature searches (Pub-med, Web of Science) and through reference lists. The search was ended by May 2001.RESULTS:
There is evidence of involvement of opioid, glutamatergic, GABAergic, noradrenergic, serotonergic and neuroendocrine pathways in the pathophysiology of PTSD. Medications shown to be effective in double-blind placebo-controlled trials includes selective serotonin reuptake inhibitors, reversible and irreversible MAO-inhibitors, tricyclic antidepressants and the anticonvulsant lamotrigine. Still more agents appear promising in open-label trials.CONCLUSION:
The complexity of the psychobiology is reflected by the difficulties in treating the disorder. According to the present knowledge, suggestions for drug treatment of PTSD are made.
Buscar en Google
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Trastornos por Estrés Postraumático
/
Péptidos Opioides
Tipo de estudio:
Clinical_trials
Límite:
Humans
Idioma:
En
Revista:
Acta Psychiatr Scand
Año:
2001
Tipo del documento:
Article
País de afiliación:
Dinamarca