DN-cadherin is required for spatial arrangement of nerve terminals and ultrastructural organization of synapses.
Mol Cell Neurosci
; 19(3): 375-88, 2002 Mar.
Article
en En
| MEDLINE
| ID: mdl-11906210
ABSTRACT
We studied roles of DN-cadherin, the Drosophila major neuronal cadherin, in neuronal connections in the visual system. In DN-cadherin mutants, axon terminals of a large subset of photoreceptor cells reached and associated with their target interneurons, but their characteristic spatial arrangement was disrupted as synaptogenesis proceeded. Although synapses were formed at contact sites between the axon terminals and target neurons, underlying cytoplasmic structures were not fully specialized at both pre- and postsynaptic terminals and synaptic vesicles appeared to accumulate at the presynapses. These results suggest that the cadherin adhesion system is required for interaction between pre- and postsynaptic terminals and for generation of the mature synaptic structures.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Cadherinas
/
Terminales Presinápticos
/
Neuronas
Límite:
Animals
Idioma:
En
Revista:
Mol Cell Neurosci
Asunto de la revista:
BIOLOGIA MOLECULAR
/
NEUROLOGIA
Año:
2002
Tipo del documento:
Article
País de afiliación:
Japón