Comparison of the antinociceptive effect of celecoxib, diclofenac and resveratrol in the formalin test.
Life Sci
; 70(14): 1669-76, 2002 Feb 22.
Article
en En
| MEDLINE
| ID: mdl-11991254
ABSTRACT
The peripheral antinociceptive effect of the selective COX-2 inhibitor celecoxib in the formalin-induced inflammatory pain was compared with that of resveratrol (COX-1 inhibitor) and diclofenac (non-selective COX inhibitor). Rats received local pretreatment with saline, celecoxib, diclofenac or resveratrol followed by 50 microl of either 1% or 5% formalin. Peripheral administration of celecoxib did not produce antinociception at either formalin concentration. In contrast, diclofenac and resveratrol produced a dose-dependent antinociceptive effect in the second phase of both 1% and 5% formalin test. The peripheral antinociception produced by diclofenac or resveratrol was due to a local action, as drug administration in the contralateral paw was ineffective. Results indicate that the selective COX-2 inhibitor celecoxib does not produce peripheral antinociception in formalin-induced inflammatory pain. In contrast, selective COX-1 and non-selective COX inhibitors (resveratrol and diclofenac, respectively) are effective drugs in this model of pain.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Estilbenos
/
Sulfonamidas
/
Antiinflamatorios no Esteroideos
/
Diclofenaco
/
Analgesia
/
Inflamación
Límite:
Animals
Idioma:
En
Revista:
Life Sci
Año:
2002
Tipo del documento:
Article
País de afiliación:
México