The asymmetrical dimethylarginine (ADMA)-multiple organ failure hypothesis.
Clin Nutr
; 22(1): 99-104, 2003 Feb.
Article
en En
| MEDLINE
| ID: mdl-12553957
ABSTRACT
Development of multiple organ failure is the most complex problem in critically ill patients, and is associated with a high mortality. Asymmetrical dimethylarginine (ADMA) is an endogenously produced inhibitor of nitric oxide synthase, of which the clinical importance is currently being revealed. In Nijveldt et al. (The liver is an important organ in the metabolism of asymmetrical dimethylargenine (ADMA) Clin Nutr 2003; 22 17-22) we showed that plasma ADMA concentration is elevated in critically ill patients and significantly related to hepatic function. Moreover, plasma ADMA concentration emerged as a strong and independent risk factor for ICU mortality in these patients. Here, we hypothesize that accumulation of ADMA is a causative factor in the development of multiple organ failure by interfering with important physiological functions of nitric oxide production.
Buscar en Google
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Arginina
/
Inhibidores Enzimáticos
/
Insuficiencia Multiorgánica
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Clin Nutr
Año:
2003
Tipo del documento:
Article
País de afiliación:
Países Bajos