Sphingosine-1-phosphate stimulates cortisol secretion.
FEBS Lett
; 535(1-3): 101-5, 2003 Jan 30.
Article
en En
| MEDLINE
| ID: mdl-12560086
ABSTRACT
We show here for the first time that sphingosine-1-phosphate (Sph-1-P) stimulates cortisol secretion in zona fasciculata cells of bovine adrenal glands. This effect was dependent upon protein kinase C (PKC) and extracellular Ca2+, and was inhibited by pertussis toxin. Sph-1-P activated phospholipase D (PLD) through a pertussis toxin-sensitive mechanism, also involving extracellular Ca2+ and PKC. Primary alcohols, which attenuate formation of phosphatidic acid (the product of PLD), and cell-permeable ceramides, which inhibit PLD, blocked Sph-1-P-induced cortisol secretion. In conclusion, Sph-1-P stimulates cortisol secretion through a mechanism involving Gi/o protein-coupled receptors, extracellular Ca2+, PKC and PLD.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Esfingosina
/
Hidrocortisona
/
Lisofosfolípidos
/
Zona Fascicular
Límite:
Animals
Idioma:
En
Revista:
FEBS Lett
Año:
2003
Tipo del documento:
Article
País de afiliación:
España