Disease-associated expression profiles in peripheral blood mononuclear cells from patients with advanced renal cell carcinoma.
Cancer Res
; 63(18): 6069-75, 2003 Sep 15.
Article
en En
| MEDLINE
| ID: mdl-14522937
ABSTRACT
Expression profiling has demonstrated that transcriptomes of primary malignancies differ from those in normal tissue. It is unknown, however, whether there exist "surrogate" transcriptional markers in peripheral blood mononuclear cells (PBMCs) of patients with solid tumors. We identified transcripts expressed differentially between PBMCs from renal cell carcinoma patients and normal subjects, some of which appear to reflect specific immune responses of circulating cells. We also identified small sets of predictor genes distinguishing PBMCs from renal cell carcinoma patients and normal volunteers with high accuracy. The present findings have important implications for diagnosis and future clinical pharmacogenomic studies of antitumor therapies.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Leucocitos Mononucleares
/
Carcinoma de Células Renales
/
Neoplasias Renales
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Cancer Res
Año:
2003
Tipo del documento:
Article
País de afiliación:
Estados Unidos