The tumor suppressor p53 inhibits Net, an effector of Ras/extracellular signal-regulated kinase signaling.
Mol Cell Biol
; 24(3): 1132-42, 2004 Feb.
Article
en En
| MEDLINE
| ID: mdl-14729959
ABSTRACT
The tumor suppressor function of p53 is linked to its ability to repress gene expression, but the mechanisms of specific gene repression are poorly understood. We report that wild-type p53 inhibits an effector of the Ras oncogene/mitogen-activated protein (MAP) kinase pathway, the transcription factor Net. Tumor-associated mutant p53s are less efficient inhibitors. p53 inhibits by preventing phosphorylation of Net by MAP kinases. Loss of p53 in vivo leads to increased Net phosphorylation in response to wound healing and UV irradiation of skin. Our results show that p53 can repress specific gene expression by inhibiting Net, a factor implicated in cell cycle entry.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Factores de Transcripción
/
Proteína p53 Supresora de Tumor
/
Proteínas Oncogénicas
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Proteínas Inmediatas-Precoces
/
Proteínas ras
/
Proteínas Quinasas Activadas por Mitógenos
Límite:
Animals
Idioma:
En
Revista:
Mol Cell Biol
Año:
2004
Tipo del documento:
Article
País de afiliación:
Francia