Aryl hydrocarbon receptor-mediated suppression of GH receptor and Janus kinase 2 expression in mice.
FEBS Lett
; 558(1-3): 96-100, 2004 Jan 30.
Article
en En
| MEDLINE
| ID: mdl-14759523
ABSTRACT
Differential mRNA display revealed that a cDNA encoding the major urinary protein 2 (MUP2) that belongs to the lipocalin superfamily was absent in livers of mice treated with 3-methylcholanthrene (MC). The expression of MUP2 is known to be stimulated by growth hormone (GH), through the GH receptor (GHR), Janus kinase 2 (JAK2) and signal transducer and activator of transcription 5 (STAT5) signal transduction pathway. Since MC is an aryl hydrocarbon receptor (AhR) ligand, the effects of MC treatment on the expression of GHR, JAK2 or STAT5 in the livers of wild-type or AhR-null mice were examined. The result indicated that the expression of GHR and JAK2 mRNA was greatly decreased by MC in wild-type mice but not in AhR-null mice. In addition, the binding activity of STAT5 bound to STAT5-binding element was reduced after MC treatment in wild-type mice but not in AhR-null mice. Based on these results, we conclude that the suppression of MUP2 mRNA expression by MC is caused by the AhR-mediated disruption of the GH signaling pathway. Possible mechanism(s) by which exposure to aromatic hydrocarbons causes a decrease in the body weight of mice, which has been referred to as wasting syndrome, will also be discussed.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Receptores de Somatotropina
/
Proteínas Tirosina Quinasas
/
Carcinógenos
/
Proteínas Proto-Oncogénicas
/
Receptores de Hidrocarburo de Aril
/
Metilcolantreno
/
Proteínas de la Leche
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
FEBS Lett
Año:
2004
Tipo del documento:
Article
País de afiliación:
Japón