Participation in normal immune responses of a metastasis-inducing splice variant of CD44.
Science
; 257(5070): 682-5, 1992 Jul 31.
Article
en En
| MEDLINE
| ID: mdl-1496383
ABSTRACT
A variant of the glycoprotein CD44 (CD44v) that shares sequences with variants causally involved in metastasis formation is transiently expressed on B and T lymphocytes and macrophages after antigenic stimulation and in the postnatal period. Antibodies to the variant hinder in vivo activation of both B and T cells. The observation that a protein domain that is expressed on CD44 and required for the lymphatic spread of tumor cells can catalyze an essential step in the process of lymphocyte activation supports the idea that metastasizing tumor cells mimic lymphocyte behavior.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Variación Genética
/
Receptores Mensajeros de Linfocitos
/
Metástasis de la Neoplasia
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
1992
Tipo del documento:
Article
País de afiliación:
Alemania