Increased alpha-linolenic acid intake lowers C-reactive protein, but has no effect on markers of atherosclerosis.
Eur J Clin Nutr
; 58(7): 1083-9, 2004 Jul.
Article
en En
| MEDLINE
| ID: mdl-15220952
ABSTRACT
OBJECTIVE:
To investigate the effects of increased alpha-linolenic acid (ALA)-intake on intima-media thickness (IMT), oxidized low-density lipoprotein (LDL) antibodies, soluble intercellular adhesion molecule-1 (sICAM-1), C-reactive protein (CRP), and interleukins 6 and 10.DESIGN:
Randomized double-blind placebo-controlled trial.SUBJECTS:
Moderately hypercholesterolaemic men and women (55 +/- 10 y) with two other cardiovascular risk factors (n = 103). INTERVENTION Participants were assigned to a margarine enriched with ALA (fatty acid composition 46% LA, 15% ALA) or linoleic acid (LA) (58% LA, 0.3% ALA) for 2 y.RESULTS:
Dietary ALA intake was 2.3 en% among ALA users, and 0.4 en% among LA users. The 2-y progression rate of the mean carotid IMT (ALA and LA +0.05 mm) and femoral IMT (ALA+0.05 mm; LA+0.04 mm) was similar, when adjusted for confounding variables. After 1 and 2 y, ALA users had a lower CRP level than LA users (net differences -0.53 and -0.56 mg/l, respectively, P < 0.05). No significant effects were observed in oxidized LDL antibodies, and levels of sICAM-1, interleukins 6 and 10.CONCLUSIONS:
A six-fold increased ALA intake lowers CRP, when compared to a control diet high in LA. The present study found no effects on markers for atherosclerosis. SPONSORSHIP The Dutch 'Praeventiefonds'.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Arteriosclerosis
/
Proteína C-Reactiva
/
Ácido alfa-Linolénico
/
Ácido Linoleico
Tipo de estudio:
Clinical_trials
/
Etiology_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Eur J Clin Nutr
Asunto de la revista:
CIENCIAS DA NUTRICAO
Año:
2004
Tipo del documento:
Article
País de afiliación:
Países Bajos