Studies on adenosine A2a receptor antagonists: comparison of three core heterocycles.
Bioorg Med Chem Lett
; 14(19): 4831-4, 2004 Oct 04.
Article
en En
| MEDLINE
| ID: mdl-15341933
ABSTRACT
Piperazine and (R)-2-(aminomethyl)pyrrolidine derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine have recently been shown to be potent and selective adenosine A(2a) receptor antagonists. We have replaced the triazolotriazine core structure with two different heterocyclic cores. One of these, the one deriving from [1,2,4]triazolo[1,5-c]pyrimidine, appears to be particularly effective and selected analogs from this series have been shown to be orally active in a mouse catalepsy model of Parkinson's disease.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Antagonistas del Receptor de Adenosina A2
/
Antiparkinsonianos
Límite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos