A case of juvenile myelomonocytic leukemia with concomitant cytomegalovirus infection.
J Pediatr Hematol Oncol
; 26(9): 606-8, 2004 Sep.
Article
en En
| MEDLINE
| ID: mdl-15342990
ABSTRACT
Infantile cytomegalovirus (CMV)-associated disease and juvenile myelomonocytic leukemia (JMML) frequently present with similar clinical features, and thus the differential diagnosis is often difficult. An early and definite diagnosis of these disorders is required because their therapeutic approaches are very different. The authors describe a 2-month-old Japanese girl with JMML and CMV infection. The CMV antigen was detected by immunologic staining of leukocytes using the peroxidase-labeled monoclonal antibody HRP-C7. To assess clonality, the X-chromosome inactivation pattern was evaluated using polymerase chain reaction analysis of the human androgen receptor gene with or without predigestion of chromosomal DNA with HhaI or HpaII. The patient showed evidence of monoclonal origin of mononuclear cells at diagnosis. Although CMV infection mimicking JMML has previously been reported in two patients, to the authors' knowledge this is the first report describing a firm and definitive diagnosis of JMML based on the study of X-chromosome inactivation patterns.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Leucemia Mielomonocítica Crónica
/
Infecciones por Citomegalovirus
Tipo de estudio:
Diagnostic_studies
Límite:
Female
/
Humans
/
Newborn
Idioma:
En
Revista:
J Pediatr Hematol Oncol
Asunto de la revista:
HEMATOLOGIA
/
NEOPLASIAS
/
PEDIATRIA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Japón