A new entry to asymmetric synthesis of optically active alpha,gamma-substituted gamma-butyrolactones, using a carbohydrate derived amide as both a chiral auxiliary and a proton source.
J Org Chem
; 70(2): 529-32, 2005 Jan 21.
Article
en En
| MEDLINE
| ID: mdl-15651797
ABSTRACT
A new entry for the asymmetric synthesis of optically active alpha,gamma-substituted gamma-butyrolactones was developed by using a carbohydrate-derived amide as both a chiral auxiliary and a proton source. Unlike the previously reported examples, the chiral auxiliary employed in this reaction also successfully functioned as a protonating agent. Excellent asymmetric induction could be achieved by this dual stereoselective control in the reaction process.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Protones
/
4-Butirolactona
/
Amidas
Idioma:
En
Revista:
J Org Chem
Año:
2005
Tipo del documento:
Article
País de afiliación:
China