[Preventive effects of montelukast on the collagen expression of pulmonary arterioles in rats with chronic hypoxia].
Sichuan Da Xue Xue Bao Yi Xue Ban
; 36(2): 213-6, 2005 Mar.
Article
en Zh
| MEDLINE
| ID: mdl-15807270
ABSTRACT
OBJECTIVE:
To evaluate the preventive effects of montelukast on the collagen expression of pulmonary arterioles in chronic hypoxic rats.METHODS:
Thirty male Wistar rats were randomly divided into three groups control group, hypoxic group and montelukast preventive group. The animal model of pulmonary hypertension was established by exposing the rats to normabaric hypoxic conditions 8 hours q.d. for 3 weeks. The expression levels of collagen I and III in arterioles were observed by immunohistochemistry.RESULTS:
The positive degree of collagen I in pulmonary arterioles of hypoxic group was higher than that of control group (1.51+/-0.09 vs 1.15+/-0.05, P<0.01), and the positive degree of collagen I in pulmonary arterioles of preventive group (1.19+/-0.06) was lower than that of hypoxic group (P<0.01). The differences of positive degree of collagen III in pulmonary arterioles were not significant among the three groups (P>0.05).CONCLUSION:
Montelukast can reduce the hypoxia-induced deposition of collagen I in the pulmonary arterioles wall.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Arteria Pulmonar
/
Quinolinas
/
Colágeno Tipo I
/
Hipertensión Pulmonar
/
Hipoxia
/
Acetatos
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
Zh
Revista:
Sichuan Da Xue Xue Bao Yi Xue Ban
Año:
2005
Tipo del documento:
Article
País de afiliación:
China