[The effect of lipoprotein lipase (LPL) polymorphism on plasma LPL concentration and triglyceride].

ABSTRACT

OBJECTIVE: To study the effect of lipoprotein lipase (LPL)-HindIII and PvuII polymorphisms on preheparin plasma LPL concentration and triglyceride. METHODS: A cross-sectional study was carried out in a general population of Beijing in 1999, using stratified-random sampling method. LPL-HindIII and PvuII polymorphism and preheparin plasma LPL concentration were determined in 670 individuals aged 45 - 64. RESULTS: (1) The frequencies of H1H1, H1H2, and H2H2 genotypes were 0.646, 0.322, and 0.031 respectively; and the frequencies of P1P1, P1P2, and P2P2 genotypes were 0.410, 0.472, and 0.118 respectively. The distribution of genotypes and that of alleles were homogeneous in both sexes. (2) The plasma LPL concentrations of the 12 type heterozygotes (H1H2 and P1P2) and those of the 22 type (H2H2 and P2P2) homozygotes were all higher than that of the 11 type homozygotes (H1H1 and P1P1) (all P < 0.01). And the LPL concentration varied greatly among different individuals of the same genotype. (3) Smoking, alcohol consumption, BMI, and waist level influenced LPL concentration more significantly in the H1H1 and P1P1 homozygotes and P1P2 heterozygotes. Multivariate analysis showed that smoking and obesity were independent influencing factors of serum LPL concentration (both P < 0.01). (4) The prevalence rate of hypertriglyceridemia was significantly different among different genotypes, the 11 type homozygotes having the highest rate, and the 22 type homozygotes having the lowest. In the same genotype, along with the increase of the serum LPL concentration the prevalence of hypertriglyceridemia decreased (P < 0.05). CONCLUSION: LPL-HindIII and PvuII polymorphisms are determinants of plasma LPL concentration. This genetic effect can be modified by some environmental factors, such as smoking and obesity.