Novel indole inhibitors of IMPDH from fragments: synthesis and initial structure-activity relationships.
Bioorg Med Chem Lett
; 16(9): 2539-42, 2006 May 01.
Article
en En
| MEDLINE
| ID: mdl-16483773
ABSTRACT
The elaboration of previously reported indole fragments as inhibitors of inosine monophosphate dehydrogenase (IMPDH) is described. The synthesis, in vitro inhibitory values for IMPDH II, PBMC proliferation and physicochemical properties are discussed.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Inhibidores Enzimáticos
/
IMP Deshidrogenasa
/
Indoles
Límite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Reino Unido