Amyloid beta protein substituent peptides do not interact with the substance P receptor expressed in cultured cells.
Brain Res Mol Brain Res
; 11(2): 177-80, 1991 Sep.
Article
en En
| MEDLINE
| ID: mdl-1661816
ABSTRACT
The amyloid beta protein (ABP) has been shown to interact with the substance P (SP) receptor in a cell culture model that may mimic the pathogenesis of Alzheimer's disease. In the present study, however, 4 fragments of ABP (beta 1-42, beta 1-16, beta 17-28, and beta 25-35) failed to interact with SP-induced Ca2+ mobilization in SP receptor-expressing cultured cells. Therefore, the action of these ABP-related peptides in our cultured cells is unrelated to the SP receptor.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neuropéptidos
/
Péptidos beta-Amiloides
/
Receptores de Neurotransmisores
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Brain Res Mol Brain Res
Asunto de la revista:
BIOLOGIA MOLECULAR
/
CEREBRO
Año:
1991
Tipo del documento:
Article