Corticosteroids can reverse severe imatinib-induced hepatotoxicity.
Haematologica
; 91(6 Suppl): ECR27, 2006 Jun.
Article
en En
| MEDLINE
| ID: mdl-16785130
ABSTRACT
BACKGROUND:
Imatinib can induce severe hepatotoxicity, in 1-5% of CML patients, many of whom need permanent imatinib discontinuation. DESIGN ANDRESULTS:
We report 5 CML patients who developed grade 3-4 hepatotoxicity after 2-8 months in imatinib. Different aetiologies of liver damage were ruled out and toxicity recurred in 2 patients with further attempts at low dose imatinib. In all patients prednisone or methylprednisolone at 25- 40 mg/day resolved hepatotoxicity in 3-8 weeks and allowed imatinib to be resumed at full doses. Corticosteroid were tapered off in 3-5 months without hepatotoxicity recurrence.CONCLUSIONS:
Corticosteroid may avoid discontinuation for hepatotoxicity of the most effective anti-CML therapy.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Piperazinas
/
Pirimidinas
/
Leucemia Mielógena Crónica BCR-ABL Positiva
/
Corticoesteroides
/
Enfermedad Hepática Inducida por Sustancias y Drogas
/
Hígado
/
Hepatopatías
/
Antineoplásicos
Límite:
Humans
Idioma:
En
Revista:
Haematologica
Año:
2006
Tipo del documento:
Article
País de afiliación:
Italia