Arylamine based cathepsin K inhibitors: investigating P3 heterocyclic substituents.
Bioorg Med Chem
; 14(20): 6807-19, 2006 Oct 15.
Article
en En
| MEDLINE
| ID: mdl-16829073
ABSTRACT
A modification of novel cathepsin K inhibitors I was carried out. The structural design was aimed at reducing the lipophilic character of compounds I for obtaining better pharmacokinetic profiles. This modification afforded several less lipophilic compounds with good inhibitory activities and pharmacokinetic profiles, although the enzyme selectivity over cathepsin S was left at issue.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Catepsinas
/
Inhibidores Enzimáticos
/
Aminas
/
Compuestos Heterocíclicos
Límite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Japón