The changes in angiogenic gene expression in recurrent multiple chorioangiomas.
Fetal Diagn Ther
; 22(3): 161-8, 2007.
Article
en En
| MEDLINE
| ID: mdl-17228150
ABSTRACT
OBJECTIVES:
To assess the messenger ribonucleic acid expression in placental tissue of growth factors, cytokines, angiogenic and anti-angiogenic factors in one case of recurrent multiple chorioangiomas.METHODS:
Complementary deoxyribonucleic acid array analysis was performed on the affected placentae and on normal placentaes (controls) to compare messenger ribonucleic acid levels of 96 genes involved in angiogenesis.RESULTS:
Eleven genes presented more than two-fold alteration in expression levels undetectable (angiopoietin 1, osteonectin, tyrosine kinase endothelial, neuropilin 1), decreased (transcription growth factor beta receptor 3, tissue inhibitor of metalloproteinase type 2, EGF receptor, integrin-alpha V, tyrosine kinase vascular endothelial growth factor receptor 2), increased (angiopoietin 2, osteopontin).CONCLUSIONS:
We illustrated the complexity of angiogenic disruption in recurrent multiple chorioangiomas leading to the difficulty to propose a single candidate gene to explain this pathology.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enfermedades Placentarias
/
Hemangioma
/
Neovascularización Patológica
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Newborn
/
Pregnancy
Idioma:
En
Revista:
Fetal Diagn Ther
Asunto de la revista:
DIAGNOSTICO POR IMAGEM
/
OBSTETRICIA
/
PERINATOLOGIA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Francia