Adaptation of renal sulfate transport in response to dietary sulfate intake in guinea pigs.
Child Nephrol Urol
; 11(2): 61-4, 1991.
Article
en En
| MEDLINE
| ID: mdl-1756521
ABSTRACT
Inorganic sulfate reabsorption was studied during sulfate infusion in guinea pigs stabilized on high-sulfate, normal-sulfate or low-sulfate diets. Guinea pigs stabilized on a low-sulfate diet exhibited 86-91% fractional sulfate reabsorption at normal plasma sulfate concentrations. Fractional renal sulfate reabsorption in animals stabilized on a high-sulfate diet was 55-70%. Clearance techniques were used to determine the glomerular filtration rate and the fractional reabsorption of sulfate during sulfate infusion. Animals fed a high-sulfate diet manifested marked sulfaturia in response to sulfate infusion. The increase in fractional reabsorption associated with decreases in dietary sulfate intake suggests a tubular adaptive mechanism, similar to that demonstrated for phosphate, to increase sulfate reabsorption and maintain constant plasma sulfate concentration. Dietary sulfate-dependent alterations in renal sulfate reabsorption may play a significant role in establishing the rate of sulfate excretion and thus regulating sulfate balance.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Sulfatos
/
Dieta
/
Riñón
Límite:
Animals
Idioma:
En
Revista:
Child Nephrol Urol
Asunto de la revista:
NEFROLOGIA
/
PEDIATRIA
Año:
1991
Tipo del documento:
Article