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Discovery of a tetrazole-based growth hormone secretagogue: 4-(hydroxybutyl)carbamic acid 2-{5-[1-(2-amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl ester (BMS-317180).
Li, Jun; Chen, Stephanie Y; Li, James J; Wang, Haixia; Hernandez, Andres S; Tao, Shiwei; Musial, Christa M; Qu, Fucheng; Swartz, Stephen; Chao, Sam T; Flynn, Neil; Murphy, Brian J; Slusarchyk, Dorothy A; Seethala, Ramakrishna; Yan, Mujing; Sleph, Paul; Grover, Gary; Smith, Mark A; Beehler, Blake; Giupponi, Leah; Dickinson, Kenneth E; Zhang, Hongjian; Humphreys, William G; Patel, Bharat P; Schwinden, Mark; Stouch, Terry; Cheng, Peter T W; Biller, Scott A; Ewing, William R; Gordon, David; Robl, Jeffrey A; Tino, Joseph A.
Afiliación
  • Li J; Department of Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, P.O. Box 5400, Princeton, NJ 08543, USA. jun.li@bms.com
J Med Chem ; 50(24): 5890-3, 2007 Nov 29.
Article en En | MEDLINE | ID: mdl-17973363
ABSTRACT
A tetrazole-based peptidomimetic 2 (BMS-317180) was discovered as a human growth hormone secretagogue (GHS). Compound 2 is a potent, novel, orally effective GHS that shows an excellent safety profile in preclinical studies. The compound was advanced into clinical development.
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Tetrazoles / Carbamatos / Hormona del Crecimiento Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2007 Tipo del documento: Article País de afiliación: Estados Unidos
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Tetrazoles / Carbamatos / Hormona del Crecimiento Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2007 Tipo del documento: Article País de afiliación: Estados Unidos