Lost your orientation? Find your way with PtdIns(3,4,5)P3!
Dev Cell
; 13(6): 753-4, 2007 Dec.
Article
en En
| MEDLINE
| ID: mdl-18061554
ABSTRACT
Faithful chromosome segregation requires correct positioning of the spindle during mitosis. In this issue of Developmental Cell, Toyoshima et al. describe a new mechanism for spindle orientation involving phosphatidylinositol-3,4,5-triphosphate [PtdIns(3,4,5)P3]. They found that in metaphase cells, dynactin was associated with the cortex through the actin cytoskeleton, and accumulated in the midsections in a PtdIns(3,4,5)P3-dependent manner. Thus, PtdIns(3,4,5)P3 regulates spindle orientation through dynein-dynactin motor complexes.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Actinas
/
Polaridad Celular
/
Fosfatos de Fosfatidilinositol
/
Metafase
/
Proteínas Asociadas a Microtúbulos
/
Huso Acromático
Límite:
Humans
Idioma:
En
Revista:
Dev Cell
Asunto de la revista:
EMBRIOLOGIA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Francia