Sulbactam-containing beta-lactamase inhibitor combinations.
Clin Microbiol Infect
; 14 Suppl 1: 185-8, 2008 Jan.
Article
en En
| MEDLINE
| ID: mdl-18154545
ABSTRACT
Sulbactam irreversibly inhibits the hydrolytic activity of beta-lactamases. This compound is commercially available in combination with either ampicillin or cefoperazone. In each instance, the activity of the partner antibiotic against beta-lactamase-producing bacteria is restored. One of the particular advantages of using sulbactam-containing combinations is that sulbactam itself has inherent activity against some Acinetobacter baumannii. Sulbactam combinations have not demonstrated strong selective pressures for extended-spectrum beta-lactamase-producing Enterobacteriaceae and vancomycin-resistant enterococci. In contrast to clavulanate, sulbactam does not induce class I (Ampc) chromosomal beta-lactamases in Enterobacteriaceae.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Sulbactam
/
Cefoperazona
/
Infecciones por Bacterias Gramnegativas
/
Inhibidores de beta-Lactamasas
/
Bacterias Gramnegativas
/
Ampicilina
Límite:
Adult
/
Humans
Idioma:
En
Revista:
Clin Microbiol Infect
Asunto de la revista:
DOENCAS TRANSMISSIVEIS
/
MICROBIOLOGIA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Turquía