Riboswitches in eubacteria sense the second messenger cyclic di-GMP.
Science
; 321(5887): 411-3, 2008 Jul 18.
Article
en En
| MEDLINE
| ID: mdl-18635805
ABSTRACT
Cyclic di-guanosine monophosphate (di-GMP) is a circular RNA dinucleotide that functions as a second messenger in diverse species of bacteria to trigger wide-ranging physiological changes, including cell differentiation, conversion between motile and biofilm lifestyles, and virulence gene expression. However, the mechanisms by which cyclic di-GMP regulates gene expression have remained a mystery. We found that cyclic di-GMP in many bacterial species is sensed by a riboswitch class in messenger RNA that controls the expression of genes involved in numerous fundamental cellular processes. A variety of cyclic di-GMP regulons are revealed, including some riboswitches associated with virulence gene expression, pilus formation, and flagellum biosynthesis. In addition, sequences matching the consensus for cyclic di-GMP riboswitches are present in the genome of a bacteriophage.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Bacterias
/
ARN Bacteriano
/
ARN Mensajero
/
Sistemas de Mensajero Secundario
/
Regulación Bacteriana de la Expresión Génica
/
GMP Cíclico
/
Aptámeros de Nucleótidos
Idioma:
En
Revista:
Science
Año:
2008
Tipo del documento:
Article
País de afiliación:
Estados Unidos