Modulating cerebello-thalamocortical pathways by neuronavigated cerebellar repetitive transcranial stimulation (rTMS).
Neurophysiol Clin
; 38(5): 289-95, 2008 Oct.
Article
en En
| MEDLINE
| ID: mdl-18940616
ABSTRACT
OBJECTIVES:
Increasing evidence suggests that dysfunctions of the cortico-cerebello-thalamocortical circuit are involved in the pathophysiology of neuropsychiatric disorders. This study explores the effects of cerebellar repetitive transcranial magnetic stimulation (rTMS) on cerebello-thalamocortical pathways.METHODS:
Ten healthy volunteers received MRI-guided rTMS in four separate sessions (120% motor threshold, 1000 stimuli) over either the medial or the right lateral cerebellum using frequencies of 1 and 10 Hz. Motor cortex excitability was assessed before and after the intervention by paired-pulse transcranial magnetic stimulation.RESULTS:
Depending on stimulation frequency, cerebellar rTMS differentially modified intracortical inhibition. Low frequency rTMS increased short intracortical inhibition (SICI), whereas high frequency rTMS had no significant effect on SICI.CONCLUSIONS:
These results suggest that rTMS over the cerebellum can modulate cerebello-thalamocortical pathways in a frequency-specific manner.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Tálamo
/
Cerebelo
/
Corteza Cerebral
/
Estimulación Magnética Transcraneal
/
Vías Nerviosas
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Neurophysiol Clin
Asunto de la revista:
FISIOLOGIA
/
NEUROLOGIA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Alemania