[Characteristics of autoimmune reactions in chronic cardiac failure of different etiology].
Ter Arkh
; 81(4): 22-8, 2009.
Article
en Ru
| MEDLINE
| ID: mdl-19514417
ABSTRACT
AIM:
To characterize autoimmune reactions in patients with chronic cardiac failure (CCF) of different etiology. MATERIAL ANDMETHODS:
Basic markers of immune activation were measured in 43 patients with coronary heart disease stage I-IIB (NYHA FC I-IV) and 44 patients with dilated cardiomyopathy (DCMP) stage I-IIB (NYHA FC I-IV). Antibodies to myocardial tissue were studied with indirect immunofluorescence. Echocardiography was made by standard recommendations with evaluation of systolic and diastolic left ventricular function. Concentrations of C-reactive protein, IgG, IgA, IgM were estimated nephelometrically. Enzyme immunoassay studied serum levels of IL-8, IL-2R, IL-6, IL-18, IL-10, IFN-gamma, endothelin.RESULTS:
Patients with DCMP had higher titers of antimyocardial autoantibodies than in coronary heart disease (CHD) reflecting more severe autoimmune inflammation. In CHD endothelial, systolic and diastolic dysfunctions severity correlated with severity of inflammation.CONCLUSION:
Some characteristics of autoimmune reactions in CCF determine severity of the disease course.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Cardiomiopatía Dilatada
/
Autoinmunidad
/
Insuficiencia Cardíaca
/
Miocardio
Tipo de estudio:
Etiology_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Ru
Revista:
Ter Arkh
Año:
2009
Tipo del documento:
Article