Increased IL-6 and IL-4 in exhaled breath condensate of patients with nasal polyposis.
Monaldi Arch Chest Dis
; 71(1): 3-7, 2009 Mar.
Article
en En
| MEDLINE
| ID: mdl-19522158
ABSTRACT
BACKGROUND AND AIM:
Nasal polyposis (NP) occurs in about 1-4% of the worldwide population. Increased plasma concentrations of different pro-inflammatory cytokines have been observed in NP, and might be related to the pathogenesis of this syndrome. The present study was designed to investigate IL-6 and IL-4 concentrations in nasal and oral exhaled breath condensate of patients with early and advanced NP, and following polypectomy.METHODS:
Ten individuals with polyposis in early status, twenty-three patients affected by advanced status of NP and ten healthy controls were enrolled into the study. Exhaled breath condensate was collected by all individuals, according to a previous standardised method. An immunoassay kit was used to measure IL-6 and IL-4 levels.RESULTS:
Concentrations of oral and nasal exhaled IL-6 and IL-4 were significantly higher in patients with early nasal polyposis and advanced nasal polyposis, compared to healthy controls. A statistically significant decrease of nasally but not of orally exhaled IL-6 (p < 0.001) and IL-4 (p < 0.05) was observed after polypectomy.CONCLUSIONS:
We consider oral and nasal exhaled condensate of IL-6 and IL-4 as valid inflammatory and oxidative stress marker in patients with nasal polyposis.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Pólipos Nasales
/
Interleucina-4
/
Interleucina-6
/
Espiración
Tipo de estudio:
Observational_studies
Límite:
Adult
/
Humans
Idioma:
En
Revista:
Monaldi Arch Chest Dis
Año:
2009
Tipo del documento:
Article