Preorganized macromolecular gene delivery systems: amphiphilic beta-cyclodextrin "click clusters".
Org Biomol Chem
; 7(13): 2681-4, 2009 Jul 07.
Article
en En
| MEDLINE
| ID: mdl-19532982
ABSTRACT
Gene delivery systems based on the beta-cyclodextrin scaffold have been synthesized by combining the copper(I)-catalyzed azide-alkyne coupling ("click chemistry") and an efficient acylation method of the secondary hydroxyls; molecular flexibility, charge density and hydrophobic-hydrophilic balance are critical parameters that can be fine-tuned by the click approach.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Técnicas de Transferencia de Gen
/
Beta-Ciclodextrinas
/
Sustancias Macromoleculares
Límite:
Animals
Idioma:
En
Revista:
Org Biomol Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2009
Tipo del documento:
Article
País de afiliación:
España