XRCC1 codon 280 and ERCC2 codon 751 polymorphisms and risk of esophageal squamous cell carcinoma in a Chinese population.
Bull Cancer
; 96(10): E61-5, 2009 Oct.
Article
en En
| MEDLINE
| ID: mdl-19762325
ABSTRACT
Numerous candidate genes have been proposed as susceptibility factors for the development of esophageal squamous cell carcinoma (ESCC). XRCC1 (X-ray cross-complementing group 1) codon 280 and ERCC2 (excision repair cross complementing group 2) codon 751 polymorphisms were studied in ESCC in a Chinese population. The aim of this study is to investigate the potential association between single-nucleotide polymorphisms (SNP) of XRCC1 codon 280 His and ERCC2 codon 751 Gln polymorphisms and ESCC. Peripheral blood samples of 200 cases and 200 age-and-gender matching controls were collected from a Chinese population and the two polymorphisms were studied by means of polymerase chain reaction (PCR) restriction fragment length polymorphism techniques. Our results showed that XRCC1 codon 280 His allele had no significant difference between ESCC patients and normal controls (P > 0.05), while ERCC2 codon 751Gln allele was associated with a borderline decrease of ESCC (odds ratio [OR] = 0.628, 95% confidence interval [CI] 0.400-0.986).
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Esofágicas
/
Carcinoma de Células Escamosas
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Polimorfismo de Nucleótido Simple
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Proteínas de Unión al ADN
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Proteína de la Xerodermia Pigmentosa del Grupo D
Tipo de estudio:
Etiology_studies
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Observational_studies
/
Risk_factors_studies
Límite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Bull Cancer
Año:
2009
Tipo del documento:
Article
País de afiliación:
China