Dihydroxylation of vinyl sulfones: stereoselective synthesis of (+)- and (-)-febrifugine and halofuginone.
J Org Chem
; 75(2): 518-21, 2010 Jan 15.
Article
en En
| MEDLINE
| ID: mdl-20000346
ABSTRACT
The asymmetric dihydroxylation of amino-functionalized vinyl sulfone 19 has been used for the 3-step preparation of 3-hydroxylpiperidine 24 in 86% enantiomeric excess. This enantiomerically enriched building block was used then to synthesize the naturally occurring antimalarial alkaloid febrifugine 1 and its antiangiogenic analogue, halofuginone 3.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Piperidinas
/
Quinazolinas
/
Sulfonas
/
Quinazolinonas
Idioma:
En
Revista:
J Org Chem
Año:
2010
Tipo del documento:
Article
País de afiliación:
Irlanda