The gelsolin:calponin complex nucleates actin filaments with distinct morphologies.
Biochem Biophys Res Commun
; 392(2): 118-23, 2010 Feb 05.
Article
en En
| MEDLINE
| ID: mdl-20035726
ABSTRACT
Gelsolin and calponin are cytoskeletal and signalling proteins that form a tight 11 complex (GCC). We show that calponin within the GCC inhibits the rate of gelsolin mediated nucleation of actin polymerization. The actin-binding function of calponin is ablated within the GCC as the actin-binding site overlaps with one of the gelsolin binding sites. The structure of filaments that result from nucleation by GCC are different to those nucleated by gelsolin alone in that they are longer, loosely bundled and stain heterogeneously with phalloidin. GCC nucleated filaments appear contorted and wrap around each to form the loose bundles.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Citoesqueleto de Actina
/
Proteínas de Unión al Calcio
/
Gelsolina
/
Proteínas de Microfilamentos
Límite:
Humans
Idioma:
En
Revista:
Biochem Biophys Res Commun
Año:
2010
Tipo del documento:
Article
País de afiliación:
Francia