Transcription of N-myc and proliferation-related genes is linked in human neuroblastoma.
Cancer Lett
; 56(1): 45-51, 1991 Jan.
Article
en En
| MEDLINE
| ID: mdl-2004353
ABSTRACT
A definite association between the transcription of N-myc oncogene and proliferation-related genes, histone H3, c-myc and p53, was found in a set of 12 primary untreated neuroblastomas and a metastasis of one of these at relapse. Molecular analysis allowed us to discriminate between actually proliferating and non-proliferating tumors, and suggested a link between N-myc and proliferation. Flow cytometric analysis of DNA distribution was less reliable for assessing tumor proliferative activity. Our data also seem to indicate a down-regulation of c-myc by N-myc in human neuroblastoma.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Transcripción Genética
/
División Celular
/
Genes myc
/
Neuroblastoma
Límite:
Child
/
Child, preschool
/
Humans
/
Infant
/
Newborn
Idioma:
En
Revista:
Cancer Lett
Año:
1991
Tipo del documento:
Article
País de afiliación:
Italia