Association of toll-like receptor 2 gene polymorphisms with normal tension glaucoma.
Mol Vis
; 15: 2905-10, 2009 Dec 26.
Article
en En
| MEDLINE
| ID: mdl-20057905
ABSTRACT
PURPOSE:
Toll-like receptor 2 (TLR2) is a transmembrane receptor that mediates immune responses to exogenous and endogenous ligands, and interacts with heat-shock proteins, which are reportedly involved in normal tension glaucoma (NTG). We investigated whether TLR2 polymorphisms are associated with NTG.METHODS:
200 Japanese patients with NTG and 128 healthy Japanese controls were recruited. We genotyped five single-nucleotide polymorphisms (SNPs) in the TLR2 gene and assessed the allele and haplotype diversities between cases and controls for all SNPs.RESULTS:
No significant differences in the frequency of TLR2 alleles and haplotypes in the NTG cases were detected, compared with the controls.CONCLUSIONS:
Our study showed no evidence for an association between TLR2 polymorphisms and NTG. TLR2 polymorphisms may not play an important role in NTG pathogenesis in the Japanese population.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Predisposición Genética a la Enfermedad
/
Polimorfismo de Nucleótido Simple
/
Receptor Toll-Like 2
/
Glaucoma de Baja Tensión
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Mol Vis
Asunto de la revista:
BIOLOGIA MOLECULAR
/
OFTALMOLOGIA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Japón