Ultrastructure of cutaneous cellular infiltrates in scleroderma.
Arch Dermatol
; 113(12): 1661-6, 1977 Dec.
Article
en En
| MEDLINE
| ID: mdl-202203
ABSTRACT
Electron microscopy of the skin was performed in ten patients with systemic and four with localized scleroderma. The following three groups of cells were identified (1) mature lymphocytes, T lymphoblasts, immature plasma cells, and plasma cells; (2) fibroblasts, fibrocytes, and fibroblast-like cells; and (3) macrophages, undifferentiated mesenchymal cells, and monocytes. Inthose specimens with mononuclear cell infiltrates, the most common cells were lymphocytic-types, macrophages, and fibroblasts with well developed rough endoplasmic reticulum. In the specimens at the fibrotic stage, fibroblasts and histiocytic-type cells predominated. This study suggests that cellular and humoral immunity may play a role in the pathophysiology of scleroderma.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Esclerodermia Localizada
/
Esclerodermia Sistémica
/
Piel
/
Cuerpos de Inclusión
Límite:
Adult
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Arch Dermatol
Año:
1977
Tipo del documento:
Article